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Hepatocellular carcinoma: Clinicopathologic associations amidst marked phenotypic heterogeneity.
Pathol Res Pract
January 2021
Institute of Liver & Biliary Sciences, D-1 Vasant Kunj, Delhi, 110070, India. Electronic address:
Background: Hepatocellular carcinoma (HCC) is characterized by marked phenotypic and molecular heterogeneity. Clinico-morphologic phenotypes and associations are important surrogate markers of molecular aberrations; therefore have immense relevance for targeted therapy. There is paucity of published literature on critical analysis of HCC heterogeneity and morphological alliance.
View Article and Find Full Text PDFAngiosarcoma and anaplastic carcinoma of the thyroid are two distinct entities: a morphologic, immunohistochemical, and genetic study.
Mod Pathol
June 2019
Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy.
Angiosarcoma and anaplastic carcinoma are the most lethal neoplasms of the thyroid worldwide and share some similarities, which have led to a longstanding controversy on their etiopathological relationship. Thyroid angiosarcomas are characterized by vessel formation and an immunophenotype common to endothelial cells, while anaplastic carcinomas are partially or wholly composed of mesenchymal-like cells that have lost the morphologic and functional features of normal thyroid follicular cells. To investigate whether angiosarcomas represent the endothelial extreme of the differentiation spectrum of carcinomas or they are bona fide vascular neoplasms, we studied the clinico-morphologic and genetic characteristics of a series of 10 angiosarcomas and 22 anaplastic carcinomas.
View Article and Find Full Text PDFClinico-morphologic and immunohystochemical characteristics of the angiogenesis were analyzed in 24 patients with malignant osseous lymphoma. Maximal density of CD-31 positive cells was registered. Immunopositivity was shown for cytoplasm and cell wall.
View Article and Find Full Text PDFThe results of clinico-morphologic and biochemical investigations of the liver were conducted in 58 patients, in whom postoperative biliary peritonitis (PBP) was revealed. There was established, that in the basement of hepatic insufficiency formation in PBP lie the hepatocytes damage and severe portal toxaemia, caused by damaging effect of the middle mass peptides and the lipids peroxidal oxidation products.
View Article and Find Full Text PDF[Autoimmune enteropathy with onset in early infancy: clinico-morphologic and immunologic manifestations].
Cas Lek Cesk
October 2002
Dĕtská klinika FN a LF UK, Plzen.
This paper describes a severely affected male infant with serious protracted diarrhoea caused by a rare autoimmune enteropathy. The disease began at 6 weeks of age of the child and it was associated with small bowel villous atrophy and the presence of circulating antienterocyte antibodies. The child was treated with steroids and with parenteral and special enteral nutrition.
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