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Therapeutic Potential of Crocin and Nobiletin in a Mouse Model of Dry Eye Disease: Modulation of the Inflammatory Response and Protection of the Ocular Surface.
Iran J Pharm Res
September 2024
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Dry eye disease (DED) is a multifactorial condition characterized by ocular surface inflammation, tear film instability, and corneal epithelial damage. Current treatments often provide temporary relief without addressing the underlying inflammatory mechanisms.
Objectives: This study examined the therapeutic potential of crocin and nobiletin, two naturally derived compounds with well-known antioxidant and anti-inflammatory properties, in a mouse model of DED induced by lacrimal gland excision (LGE).
Orbicularis Oculi Transpalpebral Pedicle Flap for the Repair of Laminar Resorption Associated With Osteo-Odonto-Keratoprosthesis.
Cornea
November 2024
Department of Ophthalmology, University of British Columbia, Vancouver, BC, Canada.
Osteo-odonto-keratoprosthesis (OOKP) is a surgical procedure reserved for severe end-stage corneal blindness with a dry, keratinized ocular surface. Late resorption of bone has been described as a complication of this procedure. We present a novel surgical technique to repair laminar resorption associated with OOKP using transpalpebral split-pedicle orbicularis oculi flaps.
View Article and Find Full Text PDFCaffeine's protective role in dry eye disease and meibomian gland dysfunction: insights from clinical and experimental models.
Int Immunopharmacol
January 2025
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Purpose: Inflammation and apoptosis contribute to the development of dry eye disease (DED) and meibomian gland dysfunction (MGD). This study aimed to investigate the effect of caffeine on the ocular surface and tear inflammatory cytokines through clinical, in vivo, and in vitro experiments.
Methods: In the clinical study, comprehensive ophthalmic examinations of participants in the control and the caffeine groups were compared, including ocular surface and tears inflammatory cytokines.
Reconstruction of rabbit corneal epithelium using adipose and / or bone marrow stem cells.
Exp Eye Res
December 2024
Anatomy and Embryology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
One of the main causes of corneal blindness is corneal alkali burn, which can also result in serious side effects such as limbal stem cell deficit, corneal perforation, and permanent epithelial abnormalities. This study set out to investigate the therapeutic potential of ADMSCs and BMMSCs for the reconstruction of the corneal surface after chemical alkali burn. Twelve adult rabbits were divided equally into four groups.
View Article and Find Full Text PDFPAX6-WNK2 Axis Governs Corneal Epithelial Homeostasis.
Invest Ophthalmol Vis Sci
October 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Article Synopsis
- Limbal stem/progenitor cells (LSCs) are crucial for maintaining the corneal epithelium and normal vision, with PAX6 being a key transcription factor that influences corneal epithelial cell differentiation.
- The study utilized RNA sequencing and other techniques to explore how PAX6 regulates the differentiation of LSCs into mature corneal epithelial cells, specifically focusing on the role of WNK2, a gene identified as a downstream target of PAX6.
- Findings showed that WNK2 expression is vital for corneal differentiation, and its deficiency disrupts normal cell markers and leads to issues like keratinization and inflammation, highlighting its importance in corneal health and potential link to corneal ulcers.
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