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Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages.
Blood
January 2025
Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan.
The maintenance of cellular redox balance is crucial for cell survival and homeostasis and is disrupted with aging. Selenoproteins, comprising essential antioxidant enzymes, raise intriguing questions about their involvement in hematopoietic aging and potential reversibility. Motivated by our observation of mRNA downregulation of key antioxidant selenoproteins in aged human hematopoietic stem cells (HSCs) and previous findings of increased lipid peroxidation in aged hematopoiesis, we employed tRNASec gene (Trsp) knockout (KO) mouse model to simulate disrupted selenoprotein synthesis.
View Article and Find Full Text PDFThe Mediating Role of Gut Microbiota on the Association Between Dietary Quality and Cancer-Related Fatigue Among Breast Cancer Patients: A Cross-Sectional Study.
Nutrients
December 2024
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Objectives: Cancer-related fatigue (CRF) is highly prevalent in patients with breast cancer, resulting in undesirable outcomes and even reduced survival rates. This cross-sectional study investigated the relationship between dietary quality and CRF in patients with breast cancer, and the potential role of gut microbiota (GM) in this association.
Methods: Dietary intake and CRF were evaluated in 342 patients, with 64 fecal samples collected for 16sRNA sequencing and 106 plasma samples for tryptophan (TRP) metabolite determination.
Anticancer Activity of Plant Tocotrienols, Fucoxanthin, Fucoidan, and Polyphenols in Dietary Supplements.
Nutrients
December 2024
Facultad de Ciencias Biológicas, Instituto de Biotecnología, Universidad Autónoma de Nuevo León, Campus Ciudad Universitaria, Av. Universidad S/N, San Nicolás de los Garza 66455, Mexico.
Plants and algae harbor diverse molecules with antioxidant activity and have been demonstrated to directly inhibit cancer cell growth and mitigate the oxidative damage associated with certain antitumor therapies. While antioxidant supplementation, either alone or in combination with chemotherapy, has shown promise in improving quality of life, further research is needed to explore the effects of antioxidant combinations on specific cancer cell lines. In this study, the in vitro cytotoxic and apoptotic properties of natural compounds derived from plants and algae, as well as certain dietary supplements, were investigated against various human cancer cell lines, including bone, leukemia, colorectal, breast, and prostate cancers.
View Article and Find Full Text PDFSafety and Efficacy of Loading Doses of Vitamin D: Recommendations for Effective Repletion.
Pharmaceuticals (Basel)
November 2024
Department of Internal Medicine and Oncology, Semmelweis University, 1085 Budapest, Hungary.
Epidemiological data on vitamin D status revealed that, despite various dosage and durations of supplementation, the effectiveness often fails to achieve optimal outcomes. The need for higher doses than previously recommended was suggested, but several modifying factors should be considered, including the level of deficiency, and BMI. The objectives of this post hoc evaluation are to characterize treatment effectiveness based on the applied dose, duration and BMI; and to assess the safety aspects associated with rapid repletion of vitamin D.
View Article and Find Full Text PDFEffects of Intercropped Insectary Plants (Sweet Alyssum, Coriander, and White Mustard) on Elemental Composition and Antioxidant Levels in Broad Bean Plants.
Molecules
December 2024
Department of Microbiology and Biomonitoring, University of Agriculture, al. A. Mickiewicza 21, 31-120 Krakow, Poland.
Insectary plants, such as sweet alyssum, coriander, and white mustard, are well known for their traits that attract beneficial insects, allowing them to protect crops from pests. The aim of the study was to analyze the compounds that are important in the antioxidant response, such as malondialdehyde, ascorbic acid, proline, total phenolics, and total flavonoids, as well as the content of elements, including macroelements (K, Mg, Na, Ca, P, and S) and heavy metals (Cd, Cu, Zn, Pb, Ni, Mn, and Fe) in broad bean plants. These plants were grown in field conditions as the main protected plant alongside a mixture of three insectary plants at different proportions of the individual components.
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