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Cryo-EM SPR structures of Salmonella typhimurium ArnC; the key enzyme in lipid-A modification conferring polymyxin resistance.
Protein Sci
February 2025
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Polymyxins are last-resort antimicrobial peptides administered clinically against multi-drug resistant bacteria, specifically in the case of Gram-negative species. However, an increasing number of these pathogens employ a defense strategy that involves a relay of enzymes encoded by the pmrE (ugd) loci and the arnBCDTEF operon. The pathway modifies the lipid-A component of the outer membrane (OM) lipopolysaccharide (LPS) by adding a 4-amino-4-deoxy-l-arabinose (L-Ara4N) headgroup, which renders polymyxins ineffective.
View Article and Find Full Text PDFCu-Ag/SBA-15 nano catalysts for the control of microorganisms in water.
Discov Nano
January 2025
Department of Physics and Chemistry, Mahatma Gandhi Institute of Technology(A), Hyderabad, 500075, India.
Because of their uniform and regular channels, adjustable pore size, large surface area, controllable wall composition, high hydrothermal stability, ease of functional modification, and good accessibility of larger reactant molecules, mesoporous siliceous SBA-15 is of excellent catalyst carrier that is highly versatile and has been used extensively to prepare a variety of supported catalysts with ideal catalytic properties. In this study, we report the synthesis, characterization, and catalytic application of Cu-Ag/ SBA-15 nanoalloy catalysts towards the control of microorganisms in drinking water has been reported. The Cu-Ag/SBA-15 nanoalloy catalysts with different molar mass ratio of copper to silver (Cu:Ag = 1: 0, 0.
View Article and Find Full Text PDFMoxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.
Life Sci Space Res (Amst)
February 2025
Department of General Surgery, the 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, PR China; Department of General Surgery, the Ninth Medical Center of PLA General Hospital, Beijing 100101, PR China. Electronic address:
Background: Currently, there is limited research on the impact of abdominal infection on intestinal damage under microgravity conditions. Cordyceps polysaccharide (CPS), the main active ingredient of Cordyceps, has demonstrated various pharmacological effects, including anti-inflammatory, antioxidant, and immunomodulatory properties. Moxifloxacin (MXF) is a fourth-generation quinolone antibiotic that is believed to have a dual regulatory effect on immune system activation and suppression.
View Article and Find Full Text PDFProtective effect of curcumin-loaded zeolitic imidazolate framework-8-based pH-responsive drug delivery system against Staphylococcus aureus infection.
Microb Pathog
January 2025
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China; Animal Disease Prevention and Control Center of Ningxia Hui Autonomous Region, Yinchuan 750001, Ningxia, P. R. China. Electronic address:
Mastitis, generally caused by pathogenic microorganisms, is a serious disease in dairy farming. Staphylococcus aureus (S. aureus) is one of the main pathogens that induces mastitis in dairy cows.
View Article and Find Full Text PDFNIR photo-responsive injectable chitosan/hyaluronic acid hydrogels with controlled NO release for the treatment of MRSA infections.
Int J Biol Macromol
January 2025
Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning 530000, China. Electronic address:
Due to resistance to common antibiotics, methicillin-resistant Staphylococcus aureus (MRSA) infections pose a significant threat to human health. In this study, we developed an injectable, adhesive, and biocompatible hydrogel with multiple functions. Specifically, carboxymethyl chitosan (CMCS) crosslinked with hyaluronic acid (HA) forms the primary framework of the hydrogel.
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