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Synergistic effect of canine FGF-21 combined with insulin in the treatment of canine diabetes.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Biopharmaceutical Lab, College of Life Science, Northeast Agricultural University, Harbin, 150030, China.
Previous studies have shown that FGF-21 can ameliorate hyperglycemia and improve the level of oxidative stress in vivo in diabetic mice. The hypoglycemic effect is safe and lasting, but it takes a longer time to exert its effect. Insulin treatment of canine diabetes takes effect quickly; however, its action time is short, and it is prone to cause hypoglycemia.
View Article and Find Full Text PDFMitigating enteric methane emissions with Madhuca longifolia phenolic extract supplementation in forages and diets through in vitro fermentation to support climate-resilient livestock production.
J Environ Manage
January 2025
Murdoch University, Murdoch, WA, 6150, Australia. Electronic address:
Reducing enteric methane emissions from livestock is a key environmental challenge, as methane is a major pollutant. The complexity of animal biology and diverse diet compositions make it difficult to develop strategy to control methane production. This study examined the use of plant phenolic extracts of Madhuca longifolia (ML-7) as a feed additive combined with various ruminant diets and dosages to find an effective supplement to reduce methane emissions.
View Article and Find Full Text PDFThe Metabolic Treatabolome and Inborn Errors of Metabolism Knowledgebase therapy tool: Do not miss the opportunity to treat!
J Inherit Metab Dis
January 2025
Department of Pediatrics, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Inborn errors of metabolism (IEMs) are rare genetic conditions with significant morbidity and mortality. Technological advances have increased therapeutic options, making it challenging to remain up to date. A centralized therapy knowledgebase is needed for early diagnosis and targeted treatment.
View Article and Find Full Text PDFMetabolomic Profiling of Reared on Chestnut Shell-Enriched Substrate Using NMR Spectroscopy.
Foods
November 2024
Department of Veterinary Medicine and Animal Sciences-DIVAS, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
The aim of this study was to evaluate the metabolomic profile of larvae reared on the following innovative growth substrates: wheat bran (control, CTRL); wheat bran supplemented with 12.5% / chestnut shell (TRT1); and wheat bran supplemented with 25% / chestnut shell (TRT2) for 14 days of trial. At the end of this experiment, larvae were transformed into insect meals for nutritional characterization.
View Article and Find Full Text PDFSPTLC3 regulates plasma membrane sphingolipid composition to facilitate hepatic gluconeogenesis.
Cell Rep
December 2024
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:
SPTLC3, an inducible subunit of the serine palmitoyltransferase (SPT) complex, causes production of alternative sphingoid bases, including a 16-carbon dihydrosphingosine, whose biological function is only beginning to emerge. High-fat feeding induced SPTLC3 in the liver, prompting us to produce a liver-specific knockout mouse line. Following high-fat feeding, knockout mice showed decreased fasting blood glucose, and knockout primary hepatocytes showed suppressed glucose production, a core function of hepatocytes.
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