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Cerebral asymmetries in schizophrenia.
Handb Clin Neurol
March 2025
Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Historically, the first observations of a lower prevalence of right-handed patients among subjects with schizophrenia led to the hypothesis that brain asymmetry could play a significant role in the etiopathogenesis of the disease. Over the last decades, a growing number of findings obtained through many different techniques such as EEG, MEG, MRI, and fMRI, consistently reported reduction/loss of brain asymmetries as a core feature of schizophrenia, further suggesting such alterations to play a cardinal role in the pathogenesis of the disease. Moreover, several cognitive and psychopathologic dimensions have shown significant correlations with the reduced degree of asymmetry.
View Article and Find Full Text PDFCharacterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach.
Psychol Med
March 2025
Orygen, Parkville, VC, Australia.
Background: To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time.
Methods: Data came from a 90-day daily diary study evaluating attenuated psychotic and affective symptoms.
Separation Anxiety and Personality Domains in a Dimensional Perspective: A Cross-Sectional Study in a Sample of Adults with Personality Disorders.
Actas Esp Psiquiatr
March 2025
Psychiatry Unit, Polyclinic Hospital University of Messina, 98125 Messina, Italy; Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy.
Background: Recent developments have highlighted the importance of separation anxiety across the lifespan, positioning it as a longitudinal psychopathological dimension. Few studies in the past decade, have explored this correlation within the context of other psychiatric disorders. This study aims to assess the presence of childhood and adulthood separation anxiety in a sample of adults with personality disorders, and its potential contribution to specific personality domains.
View Article and Find Full Text PDFThe role of attachment and parental bonding in the psychosocial assessment of transplant candidates: a cross-sectional study.
BMC Psychol
March 2025
Vascular Surgery and Organ Transplant Unit, Department of General Surgery and Medical-Surgical Specialties, University Hospital of Catania, Via Santa Sofia, 84, 95123, Catania, Italy.
Background: Kidney transplant involves profound psychological, relational, and social changes for both the patients and their family context. Occasionally, the family or social support can be deemed "dysfunctional" as it fails to fully comprehend the patient's needs and requirements. Attachment style, which pertains to the motivation to seek proximity and care in relationships with caregivers, has a significative role in the social support system for transplant, therapeutic adherence, and maintenance of the transplanted organ.
View Article and Find Full Text PDFComparison of the long-term outcome of home vs. inpatient treatment: 18-24 months follow-up of a non-randomized controlled trial.
Eur Child Adolesc Psychiatry
March 2025
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111, Stöckli, Bern, 3000, 60, Switzerland.
Home Treatment (HT) in child and adolescent psychiatry is an increasingly important topic in the current context of global crises and strained mental health systems. We implemented a HT program provided by a multiprofessional treatment team and compared long-term outcomes of 27 patients (48% female, Ø15.15 ± 2.
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