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Survival Analysis of Liver Transplants in Patients with Acute Liver Failure from Acetaminophen and Mushroom Toxicity.
Ann Transplant
January 2025
Department of General Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND Acute liver failure (ALF) remains a critical concern, accounting for about 8% of all liver transplants, with acetaminophen overdose contributing to nearly half of these cases. Besides synthetic toxins, natural toxins such as phallotoxin from Amanita phalloides mushrooms also lead to severe hepatocyte damage. This study investigates the outcomes of liver transplantation (LT) as a life-saving intervention in patients suffering from ALF due to acetaminophen and Amanita phalloides poisoning.
View Article and Find Full Text PDFPolyphenolic Hispolon Derived from Medicinal Mushrooms of the and Genera Promotes Wound Healing in Hyperglycemia-Induced Impairments.
Nutrients
January 2025
Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Yanpu Township 90741, Taiwan.
: This study investigated the wound-healing potential of hispolon, a polyphenolic pigment derived from medicinal mushrooms, under diabetic conditions using both in vitro and in vivo models. : In the in vitro assays, L929 fibroblast cells exposed to high glucose (33 mmol/L) were treated with hispolon at concentrations of 2.5, 5, 7.
View Article and Find Full Text PDFDetection and Identification in Reported Mushroom Poisoning Incidents - China, 2012-2023.
China CDC Wkly
December 2024
State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, China.
What Is Already Known About This Topic?: Mushroom poisoning incidents are one of the major causes of death by foodborne outbreaks in China. Effective detection and identification can provide the foundation for determining the cause of the incidents and the early diagnosis and treatment of patients.
What Is Added By This Report?: The surveillance data from the Public Health Emergency Management Information System, China CDC, showed that incidents with laboratory test results as the basis for determining the cause of mushroom poisoning accounted for only 14.
The Role of AFB1, OTA, TCNs, and Patulin in Forensic Sciences: Applications in Autopsy, Criminal Investigations, and Public Health Prevention.
Toxins (Basel)
November 2024
Institute of Legal Medicine, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
Mycotoxins, specifically aflatoxin B1 (AFB1), ochratoxin A (OTA), trichothecenes (TCNs), and patulin, are a group of secondary metabolites that can contaminate food, leading to severe health implications for humans. Their detection and analysis within forensic toxicology are crucial, particularly as they can be implicated in cases of poisoning, foodborne illnesses, or lethal chronic exposure. However, little is known about the application that mycotoxins could have in forensic investigations and especially about the possibility of extracting and quantifying these molecules on tissues or post-mortem fluids collected at autopsy.
View Article and Find Full Text PDFInhibitory Effects of the Methanol Extract of the Golden Chanterelle Mushroom, Cantharellus cibarius (Agaricomycetes) in Treating a Human Acute Myeloid Leukemia Cell Line.
Int J Med Mushrooms
December 2024
College of Arts & Sciences, University of Pikeville, Pikeville, KY 41501, USA.
Article Synopsis
- Current treatments for acute myeloid leukemia (AML) face challenges due to side effects and resistance issues.
- This study explores the anticancer potential of extracts from the edible mushroom Cantharellus cibarius on the MV4-11 AML cell line.
- A specific fraction, LH-20F-IV, demonstrated the highest inhibitory effect on the leukemia cells, indicating the mushroom may contain promising anticancer compounds.
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