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Imbalanced VWF-ADAMTS13 axis contributes to the detrimental impact of a preceding respiratory tract infection on stroke.
Blood Adv
January 2025
University of Iowa, Iowa city, Iowa, United States.
Respiratory tract infections (RTIs) caused by bacteria or viruses are associated with stroke severity. Recent studies have revealed an imbalance in the von Willebrand factor (VWF)-ADAMTS13 axis in patients with RTIs, including COVID-19. We examined whether this imbalance contributes to RTI-mediated stroke severity.
View Article and Find Full Text PDFBackground: An intact blood-brain barrier (BBB) is critical for optimal brain health, and even transient or highly localized disruption of the BBB can have devastating consequences for neural functioning. BBB breakdown has been implicated in Alzheimer's Disease (AD) pathogenesis, and elevated BBB permeability has been observed in APOE e4 carriers compared to non-carriers. As prior studies have focused on a priori, AD-vulnerable regions rather than whole-brain analyses, little is understood about broader patterns of BBB breakdown that may relate to AD risk.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Background: Maintaining functional independence is an essential aspect of healthy aging. In fact, functional dependence to perform activities of daily living (ADL) is a fundamental part of a dementia diagnosis. Newer diagnostic criteria for MCI also consider functional impairments (FI) but not to the extent of compromising functional independence.
View Article and Find Full Text PDFBackground: Early changes in network activity serve as distinctive hallmarks in tauopathies such as Alzheimer's Disease and Frontotemporal Dementia. Decades before the onset of cognitive decline, many patients experience seizures which exacerbate the condition. Despite the recognised etiological overlaps between tauopathies and epilepsies, the relationship between tau and the development of circuit hyperexcitability is unclear and needs further investigation.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: Higher order regulation of autonomic function is maintained by cortical and subcortical interconnected regions within the brain, collectively referred to as the central autonomic network (CAN) (Benarroch, 1993). Despite the well-established relationship between autonomic dysfunction and AD (Femminella et al., 2014) the relationship between CAN functional connectivity and biomarkers of AD, such as Ab ratio, remains unexplored.
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