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Candida auris is an emerging, multidrug-resistant fungus that poses a threat in health care settings because of its persistence on surfaces and ability to cause severe infections, particularly in immunocompromised patients. First identified in Japan in 2009, C auris has since spread globally, leading to numerous outbreaks. Its unique virulence factors, such as biofilm formation and immune evasion, contribute to its resilience and resistance to eradication.
View Article and Find Full Text PDF[Investigation of the Antifungal Susceptibility and Virulence Factors of Fusarium Strains Isolated from Clinical Samples].
Mikrobiyol Bul
January 2025
Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Aydın.
Fusarium türleri, insanlarda keratit ve onikomikoz başta olmak üzere invaziv veya invaziv olmayan çeşitli enfeksiyonlarda etken olan küf mantarlarıdır. Taksonomide Fusarium cinsi, tür kompleks [species complex (SC)]'lere ayrılmış, SC'ler de türlere ayrılmıştır. SC/tür düzeyinde identifikasyonun, morfolojik özelliklere göre yapılmasının güçlüğü nedeniyle moleküler yöntemlerin kullanımı önerilmektedir.
View Article and Find Full Text PDFAntifungal activity of 2-adamantylamine hydrochloride on and .
J Med Microbiol
January 2025
Department of Stem Cell and Regenerative Medicine, Medical Biotechnology, Centre for Interdisciplinary Research, D.Y. Patil Education Society (Deemed to be University), Kolhapur- 416-003, Maharashtra, India.
Increased virulence and drug resistance in species of resulted in reduced disease control and further demand the development of potent antifungal drugs. The repurposing of non-antifungal drugs and combination therapy has become an attractive alternative to counter the emerging drug resistance and toxicity of existing antifungal drugs against and non-albicans species. This study aimed to accelerate antifungal drug development process by drug repurposing approach.
View Article and Find Full Text PDFHost cell responses to biofilm-derived extracellular vesicles.
Front Cell Infect Microbiol
January 2025
Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
is a prevalent fungal pathogen responsible for infections in humans. As described recently, nanometer-sized extracellular vesicles (EVs) produced by play a crucial role in the pathogenesis of infection by facilitating host inflammatory responses and intercellular communication. This study investigates the functional properties of EVs released by biofilms formed by two strains-3147 (ATCC 10231) and SC5314-in eliciting host responses.
View Article and Find Full Text PDFRisk Factors and Outcomes of Invasive Candida Infections in Heart Transplant Recipients: A Case-Control Study.
Clin Transplant
February 2025
Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
Background: Invasive Candida infections (ICI) are the most common invasive fungal infections in solid organ transplant recipients. There are limited contemporary data on the risk factors for infection in heart transplant (HT) recipients especially since the expansion of temporary mechanical circulatory support (MCS) use.
Methods: This was a case-control study conducted at a tertiary care academic hospital of HT recipients from January 2022 to January 2024.
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