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Polymorphic lymphoproliferative disorder arising in a rheumatoid arthritis patient, presenting as fibrin-associated large B-cell lymphoma-like lesions in aortic and mitral valves.
Pathol Int
May 2024
Department of Diagnostic Pathology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
We herein report a case of methotrexate-associated lymphoproliferative disorder (MTX-LPD) showing fibrin-associated large B-cell lymphoma-like heart valve lesions, and Epstein-Barr virus (EBV)-positive mucocutaneous ulcer-like cutaneous and oral mucosal lesions. MTX-LPD is a critical complication that can occur in RA patients who are treated with MTX. EBV also plays a defining or important role in LPDs.
View Article and Find Full Text PDFAntibiotic-Induced Gut Microbiota Depletion Accelerates the Recovery of Radiation-Induced Oral Mucositis in Rats.
Int J Radiat Oncol Biol Phys
July 2022
School of Biomedicine, University of Adelaide, Adelaide.
Purpose: Due to its pivotal role in the modulation of immune and inflammatory responses, the gut microbiota has emerged as a key modulator of cancer treatment-induced gastrointestinal mucositis. However, it is not clear yet how it affects radiation therapy-induced oral mucositis (OM). As such, this study aimed to explore the gut microbiota's role in the pathogenesis of radiation-induced OM in rats.
View Article and Find Full Text PDFMycotic Aortic Arch Aneurysm Caused by Clostridium perfringens.
Cureus
January 2022
Department of Cardiovascular Surgery, Juntendo University School of Medicine, Tokyo, JPN.
We report a case of a 79-year-old man for a mycotic aortic arch aneurysm caused by . The patient who had been hospitalized for cholangitis two months prior revisited the hospital for fever and left precordial pain. He was suspected of an infected aortic aneurysm in the distal arch due to emphysematous changes observed.
View Article and Find Full Text PDFEndovascular repair for retrograde type A intramural hematoma with focal intimal disruption in descending aorta.
J Thorac Dis
July 2021
Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
Background: This study aims to report the experience of a single center using thoracic endovascular aortic repair (TEVAR) to treat retrograde type A intramural hematoma (IMH) with focal intimal disruption (FID) in descending aorta.
Methods: A total of 24 consecutive patients with retrograde type A IMH and complicated with FID in descending aorta underwent TEVAR in our center from 2015 to 2020. Their clinical data, imaging manifestation and follow-up results were retrospectively reviewed and analyzed.
Identification of upper gastrointestinal malignancy in patients with uncomplicated dyspepsia referred under the two-week-wait cancer pathway: a single-centre, 10-year experience.
Eur J Gastroenterol Hepatol
January 2020
Consultant Gastroenterologist, Queen Elizabeth Hospital, London, United Kingdom.
Introduction: In the United Kingdom, the National Institute for Health and Care Excellence 2015 guidance recommend that for suspected gastric or oesophageal cancer, general practitioners consider a non-urgent, direct-access endoscopy in patients over 55 years with only uncomplicated treatment-resistant dyspepsia. In practice, patients are referred under the urgent 2-week-wait cancer pathway.
Methods: We compared the frequency of gastric or oesophageal carcinoma in patients referred to our centre on the 2-week-wait pathway with uncomplicated dyspepsia to those who have a combination of additional alarm symptoms.
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