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BMP4-GPX4 can improve the ferroptosis phenotype of retinal ganglion cells and enhance their differentiation ability after retinal stem cell transplantation in glaucoma with high intraocular pressure.
Hum Mol Genet
January 2025
Ophthalmology Department, Tongxiang First People's hospital, No. 1918 Jiaochang East Road, Tongxiang, Zhejiang 314500, China.
Activation of bone morphogenetic protein (BMP) 4 signaling promotes the survival of retinal ganglion cell (RGC) after acute injury. In this study, we investigated the role of the BMP4 signaling pathway in regulating the degeneration of retinal ganglion cells (RGCs) in a mouse glaucoma model and its potential application in retinal stem cell. Our results demonstrate that BMP4-GPX4 not only reduces oxidative stress and iron accumulation but also promotes neuroprotective factors that support the survival of transplanted RSCs into the host retina.
View Article and Find Full Text PDFPolydipsia Induced Acute Angle-Closure Crisis.
J Glaucoma
January 2025
Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
We present a case of Acute Angle-Closure Crisis (AACC) precipitated by primary transient psychogenic polydipsia; we believe that our case is the first of its kind to be reported. A 74-year-old male presented to the emergency department with altered mental status due to acute-onset hyponatremia. Six days after admission, the patient noticed painful loss of vision in his right eye and an ipsilateral headache lasting 10-15 minutes.
View Article and Find Full Text PDFValue of MRI-based radiomics models for predicting visual outcome in patients with MOG-optic neuritis: A preliminary study.
Eur J Ophthalmol
January 2025
Department of Radiology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, China.
Purpose: To investigate the predictive value of MRI-based radiomics models for the recovery of visual acuity after 12 months in patients with acute phase MOG-optic neuritis(MOG-ON).
Materials And Methods: Clinical and MRI imaging data were collected consecutively from January 2021 to April 2022 from patients with acute stage MOG-ON, and the visual acuity of patients were followed up after 12 months. After stratified random sampling, patients were divided into training and test sets, and prediction models based on CE-T1WI, FS-T2WI, and combined CE-T1WI and FS-T2WI were developed.
Topical brinzolamide-induced ciliary body effusion with secondary angle closure and myopic shift.
BMJ Case Rep
January 2025
Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Here, we describe a rare case of drug-induced unilateral ciliary body effusion precipitated by topical brinzolamide, presenting acutely with pain, angle closure and myopic shift.Ciliary body effusion was suspected clinically and confirmed by ultrasound biomicroscopy. Brinzolamide was ceased, atropine instilled and the ciliary body effusion promptly resolved without need for further treatment.
View Article and Find Full Text PDFAcute angle-closure glaucoma risk: a comparative study of escitalopram and antidepressants.
Can J Ophthalmol
January 2025
University of British Columbia, Vancouver, British Columbia, Canada.
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