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The Issue of "Smart Drugs" on the Example of Modafinil: Toxicological Analysis of Evidences and Biological Samples.
J Xenobiot
January 2025
Department of Social Sciences and Infectious Diseases, Faculty of Medicine, Wroclaw University of Science and Technology, 27 Wybrzeze Wyspianskiego Street, 50370 Wroclaw, Poland.
Cognitive enhancement through stimulants such as modafinil is becoming increasingly popular, with many individuals using prescription stimulants for non-medical purposes to improve alertness, attention, and mood. The misuse of such substances has raised concerns, particularly in forensic toxicology. The UHPLC-QqQ-MS/MS method was developed to quantify modafinil in evidentiary samples and biological materials.
View Article and Find Full Text PDFPhylogenetic signal in primate tooth enamel proteins and its relevance for paleoproteomics.
Genome Biol Evol
January 2025
Institut Català de Paleontologia Miquel Crusafont (ICP-CERCA), Universitat Autònoma de Barcelona, Edifici ICTA-ICP, Cerdanyola del Vallès, Barcelona, Spain; Unidad de Paleobiología, ICP-CERCA, Unidad Asociada al CSIC por el IBE UPF-CSIC, Cerdanyola del Vallès, Barcelona, Spain; Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.
Ancient tooth enamel, and to some extent dentin and bone, contain characteristic peptides that persist for long periods of time. In particular, peptides from the enamel proteome (enamelome) have been used to reconstruct the phylogenetic relationships of fossil taxa. However, the enamelome is based on only about 10 genes, whose protein products undergo fragmentation in vivo and post mortem.
View Article and Find Full Text PDFRadiocarbon and bomb pulse dating in the forensic context: A systematic review.
Forensic Sci Int
January 2025
Forensic Medicine, Forensic Science and Sports Medicine Section, Department of Medicine and Surgery, University of Perugia, Piazza Lucio Severi, Perugia, Italy. Electronic address:
Radiocarbon analysis in bones, particularly through Bomb Pulse dating, is an essential tool in forensic investigations for estimating the postmortem interval of human remains. However, there are some limitations related to the interpretation of laboratory data, since this can differ from the Post Mortem Interval by many years, depending on the anatomical district and the bone part sampled, as well as the age of the individual and other parameters, since these elements influence bone turnover. In recent years, many studies have been conducted, but with non-standardized data and on limited samples.
View Article and Find Full Text PDFDevelopment and validation of headspace gas chromatography with a flame ionization detector method for the determination of ethanol in the vitreous humor.
Open Med (Wars)
January 2025
Department of Toxicological Chemistry, National Poison Control Center, Military Medical Academy, Belgrade, 11000, Serbia.
Introduction: Qualitative and quantitative testing of ethanol in samples is an important analytical procedure that provides accurate, precise, and reliable results. Given the complexity of the issue, obtaining a realistic picture of lifelong alcoholemia requires supporting blood ethanol findings with analyses of alternative samples, primarily vitreous humor (VH).
Objective: The objective of this study was to develop and validate a headspace gas chromatography with flame ionization detection (HS/GC-FID) method for determining ethanol concentration in VH.
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