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Powder Self-Emulsifying Drug Delivery System for Mitotane: In Vitro and In Vivo Evaluation.
Pharmaceutics
September 2024
Normandie Univ., UNIROUEN, INSERM, NORDIC UMR 1239, F-76000 Rouen, France.
Article Synopsis
- Drug Delivery Systems (DDSs) can enhance the effectiveness of treatments by improving drug solubility and bioavailability, particularly for drugs like mitotane used in treating adrenocortical cancer.
- The research develops a new powder self-emulsifying drug delivery system (P-SEDDS) for mitotane to overcome its low oral bioavailability and improve therapeutic effects while reducing side effects.
- Results showed that the P-SEDDS significantly increased the bioavailability of mitotane, suggesting it could be a more effective approach compared to traditional formulations.
Development and validation of a liquid chromatography coupled to a diode array detector (LC-DAD) method for measuring mitotane (DDD) in plasma samples.
Clinics (Sao Paulo)
August 2024
Laboratório de Hormônios e Genética Molecular LIM-42, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil; Núcleo Multiusuário de Cromatografia Líquida Associada à Espectrometria de Massas em Tandem, (AE-06 Rede Premium), Brazil. Electronic address:
Introduction: Mitotane (o,p'-DDD) is the drug of choice for Adrenocortical Carcinomas (ACC) and its measurement in plasma is essential to control drug administration.
Objective: To develop and validate a simple, reliable and straightforward method for mitotane determination in plasma samples.
Method: Drug-free plasma samples were collected in potassium-ethylenediamine tetraacetate (K-EDTA) tubes and spiked with 1.
Compatibility of cloud point extraction with gas chromatography: Matrix effects of Triton X-100 on GC-MS and GC-MS/MS analysis of organochlorine and organophosphorus pesticides.
Talanta
March 2024
Institute of Chemical Technologies and Analytics, Vienna University of Technology, 1060 Vienna, Austria. Electronic address:
Cloud point extraction is an environmentally benign and simple separation/concentration procedure that can be regarded as an alternative to classical liquid-liquid extraction. In the current work, it was studied the compatibility of cloud point extraction followed by back-extraction in low volume of organic solvent with gas chromatography-mass spectrometry (GC-MS and GC-MS/MS). Triton X-100 was preferred than Triton X-114 as a surfactant to produce the clouding phenomenon and hexane or isooctane was found to be appropriate organic solvents which can be used at the back-extraction step.
View Article and Find Full Text PDFInvestigation of the Relationship between Spontaneous Abortion, Serum Pesticides, and Polychlorinated Biphenyl Levels.
Toxics
October 2023
Department of Obstetrics and Gynecology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, Turkey.
Occupational and environmental chemical exposure have been associated with adverse reproductive consequences. This study investigates the relationship between spontaneous abortion and blood pesticide and polychlorinated biphenyl (PCB) levels. A survey was conducted, and blood samples were collected from 200 patients, consisting of 100 cases with spontaneous abortion and 100 cases with normal deliveries.
View Article and Find Full Text PDFThe dynamics of persistent organic pollutant (POP) transfer from female bottlenose dolphins (Tursiops truncatus) to their calves during lactation.
Sci Total Environ
January 2024
U.S. Navy Marine Mammal Program, Naval Information Warfare Center Pacific, San Diego, CA, USA.
Persistent organic pollutants (POPs) are lipophilic compounds that can accumulate in high concentrations in the blubber of marine mammals, which are long-lived, top-level predators in their ecosystems. These compounds, which include DDTs, PCBs, PBDEs, HCHs, and CHLDs, impact mammalian health, including neurological effects, reduced immune system efficiency, and reproductive failure. POPs are transferred from females to their offspring during gestation and lactation, which have implications for the health of newborn marine mammals, particularly first-born offspring who receive higher concentrations.
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