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Role of astrocytes connexins - pannexins in acute brain injury.
Neurotherapeutics
January 2025
Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile. Electronic address:
Acute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants. In this regard, astroglial connexin and pannexin channels have been shown to play an important role. These channels are transmembrane proteins sharing similar topology and form gateways between adjacent cells named gap junctions (GJs) and pores into unopposed membranes named hemichannels (HCs).
View Article and Find Full Text PDFThe impact of adverse childhood experiences on pain and subjective cognitive decline in patients treated for localized breast cancer: The mediating role of sense of coherence, sense of danger and psychosocial distress and danger.
Breast
January 2025
Oncology Division, Rambam Health Care Campus, HaAliya HaShniya St 8, Haifa, 3109601, Israel; Bruce Rappaport Faculty of Medicine, Technion Israeli Institute of Technology, Efron St 1, Haifa, 3525433, Israel. Electronic address:
Background: Pain and subjective cognitive decline (SCD) are common sequala of breast cancer (BC) treatment. Adverse childhood experiences (ACEs) are associated with pain and adverse health outcomes in noncancer population. Sense of coherence (SOC) reflects the disposition that life is manageable and predictable.
View Article and Find Full Text PDFAI-pocalypse now: Automating the systematic literature review with SPARK (Systematic processing and automated review Kit) - gathering, organising, filtering, and scaffolding.
MethodsX
June 2025
School of Social Sciences, University of Tasmania, Tasmania 7005, Australia.
Researchers today face significant challenges reshaping the landscape of academic, government, and industry research due to the exponential growth of global research outputs and the advent of Generative Artificial Intelligence (GenAI). The annual increase in published works has made it difficult for traditional literature review and data analysis methods to keep pace, often rendering reviews outdated by the time of publication. In response, this methods article introduces a suite of new tools designed to automate a number of stages for systematic literature reviews.
View Article and Find Full Text PDFResearch on leakage and diffusion behavior of hydrogen doped natural gas in integrated pipeline corridors based on data drive.
Sci Rep
January 2025
Northwest Sichuan Gas District of Southwest Oil and Gasfield Company, Jiangyou, 621700, China.
With the wide application of hydrogen-doped natural gas (HBNG) in end users, laying pipelines in urban, comprehensive pipe corridors has become increasingly common. However, the leakage and diffusion of hydrogen-doped natural gas in confined or semi-confined spaces (e.g.
View Article and Find Full Text PDFHigh-fat diet and neuroinflammation: the role of mitochondria.
Pharmacol Res
January 2025
Department of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, 250012, P R China. Electronic address:
In recent years, increasing evidence has supported that high-fat diet (HFD) can induce the chronic, low-grade neuroinflammation in the brain, which is closely associated with the impairment of cognitive function. As the key organelles responsible for energy metabolism in the cell, mitochondria are believed to involved in the pathogenesis of a variety of neurological disorders. This review summarizes the current progress in the field of the relationship between HFD exposure and neurodegenerative diseases, and outline the major routines of HFD induced neuroinflammation and its pathological significance in the pathogenesis of neurodegenerative diseases.
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