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It's a good thing that severely hypoxic salmon (Salmo salar) have a limited capacity to increase heart rate when warmed.
J Exp Biol
January 2025
Department of Ocean Sciences, Memorial University of Newfoundland and Labrador, St. John's, NL. A1C 5S7, Canada.
With climate change, fish are facing rising temperatures, an increase in the frequency and severity of heat waves and hypoxia, sometimes concurrently. However, only limited studies have examined the combined effects of increases in temperature and hypoxia on fish physiology and survival. We measured the cardiorespiratory physiology of 12°C-acclimated Atlantic salmon when exposed acutely to normoxia [100% air saturation (sat.
View Article and Find Full Text PDFEnhanced porphyrin-based hypoxia imaging by temporal oversampling of delayed fluorescence signal.
J Biomed Opt
February 2025
University of Wisconsin-Madison, Department of Medical Physics, Madison, Wisconsin, United States.
Significance: Protoporphyrin IX (PpIX) delayed fluorescence (DF) is inversely related to the oxygen present in tissues and has potential as a novel biomarker for surgical guidance and real-time tissue metabolism assessment. Despite the unique promise of this technique, its successful clinical translation is limited by the low intensity emitted.
Aim: We developed a systematic study of ways to increase the PpIX DF signal through acquisition sampling changes, allowing optimized imaging at video rates.
Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury.
Front Pharmacol
January 2025
Waisman Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States.
Introduction: 7,8-Dihydroxyflavone (7,8-DHF) is a promising translational therapy in several brain injury models, including the neonatal hypoxia-ischemia (HI) model in mice. However, the neuroprotective effect of 7,8-DHF was only observed in female, but not male, neonatal mice with HI brain injury. It is unknown whether HI-induced physiological changes affect brain distribution of 7,8-DHF differently for male versus female mice.
View Article and Find Full Text PDFHydroxyacyl-coenzyme A dehydrogenase: A biomarker for authentication of death from mechanical asphyxia.
Forensic Sci Int
January 2025
Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, 131 Dong'an Road, Shanghai 200032, PR China. Electronic address:
Death from mechanical asphyxia (DMA) refers to death from acute respiratory disorder caused by mechanical violence. Due to the absence of characteristic signs in corpses, it has been rather challenging to achieve the precise authentication of DMA. In this research, human pulmonary samples were collected and grouped according to different causes of death in search of potential biomarkers of DMA.
View Article and Find Full Text PDFChewing-Activated TRPV4/PIEZO1--Zn Axes in a Rat Periodontal Complex.
J Dent Res
January 2025
Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco, CA, USA.
The upstream mechanobiological pathways that regulate the downstream mineralization rates in periodontal tissues are limitedly understood. Herein, we spatially colocalized and correlated compression and tension strain profiles with the expressions of mechanosensory ion channels (MS-ion) TRPV4 and PIEZO1, biometal zinc, mitochondrial function marker (), cell senescence indicator (), and oxygen status marker hypoxia-inducible factor-1α () in rats fed hard and soft foods. The observed zinc and related cellular homeostasis in vivo were ascertained by TRPV4 and PIEZO1 agonists and antagonists on human periodontal ligament fibroblasts ex vivo.
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