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Adverse effects associated with antipsychotic use in older adults.
Expert Opin Drug Saf
September 2024
Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, Texas, USA.
Introduction: Antipsychotic (AP) medications are extensively utilized for diverse psychiatric and non-psychiatric conditions, but they are associated with significant adverse effects in older adults. This expert opinion review provides an updated profile of adverse effects associated with AP medications in older adults.
Areas Covered: This review specifically examines real-world evidence for adverse events associated with AP use, including all-cause mortality, falls and fractures, diabetes, cardiovascular and cerebrovascular events, acute kidney injury, venous thromboembolism/pulmonary embolism, extrapyramidal symptoms, and infections based on real-world evidence.
Therapeutic dilemma's: antipsychotics use for neuropsychiatric symptoms of dementia, delirium and insomnia and risk of falling in older adults, a clinical review.
Eur Geriatr Med
August 2023
School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Purpose: Because of the common and increasing use of antipsychotics in older adults, we aim to summarize the current knowledge on the causes of antipsychotic-related risk of falls in older adults. We also aim to provide information on the use of antipsychotics in dementia, delirium and insomnia, their adverse effects and an overview of the pharmacokinetic and pharmacodynamic mechanisms associated with antipsychotic use and falls. Finally, we aim to provide information to clinicians for weighing the benefits and harms of (de)prescribing.
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Ugeskr Laeger
February 2023
Neurologisk Afdeling, Sjællands Universitetshospital, Roskilde.
Creutzfeldt-Jakob disease is the most common prion disease in humans. Neuropsychiatric symptoms are common, and objective findings are myoclonus, pyramidal and extrapyramidal including cerebellar dysfunction. This is a case report of a 77-year-old woman with gradual onset of repeated falls due to cerebellar dysfunction.
View Article and Find Full Text PDFNeurological complications in pediatric liver transplant recipients.
Pediatr Transplant
December 2022
Department of Hepatobiliary Surgery & Liver Transplantation, Dr Rela Institute & Medical Centre, National Foundation for Liver Research, Bharath Institute of Higher Education and Research, Chennai, India.
Introduction: There is paucity of data on neurological complications (NCs) and its predisposing factors, in pediatric liver transplant (PLT) recipients.
Methods: Records of seventy-one children who underwent LT between October 2018 and November 2019 were reviewed. Patients were categorized into group A: with NC and group B: without NC in the post-LT period.
Intramuscular midazolam, olanzapine, or haloperidol for the management of acute agitation: A multi-centre, double-blind, randomised clinical trial.
EClinicalMedicine
February 2021
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR.
Background: The safety and effectiveness of intramuscular olanzapine or haloperidol compared to midazolam as the initial pharmacological treatment for acute agitation in emergency departments (EDs) has not been evaluated.
Methods: A pragmatic, randomised, double-blind, active-controlled trial was conducted from December 2014 to September 2019, in six Hong Kong EDs. Patients (aged 18-75 years) with undifferentiated acute agitation requiring parenteral sedation were randomised to 5 mg intramuscular midazolam ( = 56), olanzapine ( = 54), or haloperidol ( = 57).
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