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Adapting the Laser-Induced Fluorescence Detection Setup of the Standard Capillary Electrophoresis Equipment to Achieve High-Sensitivity Detection of 2-Aminoacridone Labeled Oligosaccharides.
J Sep Sci
March 2025
Institute of Analytical Chemistry of the Czech Academy of Sciences, Brno, Czech Republic.
The high-sensitivity capabilities of laser-induced fluorescence (LIF) detection continuously promote the development of various labels with different fluorescence properties. However, this strategy also requires the adaptation of existing detection systems to suit the excitation and emission characteristics of novel fluorescent tags. In this study, we adapted the LIF detector of the commercial capillary electrophoresis instrument to the specific fluorescence spectra of 2-aminoacridone labeled human milk oligosaccharides.
View Article and Find Full Text PDFmPEG-PCL modified Caffeic acid eye drops for endotoxin-induced uveitis treatment.
Sci Rep
March 2025
State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China, 325000.
The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties, holds therapeutic potential but suffers from poor solubility and ocular irritation.
View Article and Find Full Text PDFA high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes.
Sci Rep
March 2025
Department of Medicine, Vanderbilt University School of Medicine, 2215 Garland Ave, Nashville, TN, 37232, USA.
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a pivotal model for research. Specialized devices can generate Extracellular Field Potential (EFP) measurements from these cells, analogous to the ventricular complex of the electrocardiogram. However, electrophysiological analysis can be complex and requires specialized expertise, posing a barrier to broader adoption in non-specialized labs.
View Article and Find Full Text PDFModelling and optimization of Ge/GaAs uni-travelling carrier photodiodes.
Sci Rep
March 2025
Department of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Uni-Travelling-Carrier Photodiodes (UTC-PDs) are pivotal for the advancement of high-speed optical communication systems. Current UTC-PDs have a trade-off between high performance and low production costs. The performance of conventional Ge/Si UTC-PDs is limited by the materials, primarily due to the relatively low electron mobility of Si compared with that of GaAs and InP.
View Article and Find Full Text PDFMultimodal machine learning for deception detection using behavioral and physiological data.
Sci Rep
March 2025
Symbiosis Institute of Technology, Symbiosis International Deemed University, Pune, India.
Deception detection is crucial in domains like national security, privacy, judiciary, and courtroom trials. Differentiating truth from lies is inherently challenging due to many complex, diversified behavioural, physiological and cognitive aspects. Traditional lie detector tests (polygraphs) have been widely used but remain controversial due to scientific, ethical, and practical concerns.
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