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Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data.
Int Forum Allergy Rhinol
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, California, USA.
Background: Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Surgery can be performed with unilateral or bilateral resection depending on extent of involvement; however, there are currently no studies comparing outcomes between the two.
View Article and Find Full Text PDFOlfactory neuroblastoma: literature review and presentation of two clinical cases with different tumour infiltrations and different approaches.
Neurocirugia (Astur : Engl Ed)
December 2024
Departamento de Neurocirugía, Fundación Oftalmológica de Santander - Clínica Ardila Lülle, Floridablanca, Colombia. Electronic address:
The olfactory neuroblastoma is a rare malignant neoplasm derived from the olfactory neuroepithelium. It can metastasize to cervical lymph node chains and distant organs through hematogenous or lymphatic routes. Two clinical cases are presented: the first, a 56-year-old man with no pathological history, exhibited symptoms evolving over 2 months, characterized by persistent rhinorrhea with frequent epistaxis, ipsilateral proptosis, left hemicranial pain, anosmia, and dysgeusia.
View Article and Find Full Text PDFEctopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.
Int Forum Allergy Rhinol
January 2025
Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.
Introduction: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
View Article and Find Full Text PDFAn Uncommon Encounter: Metastatic Olfactory Neuroblastoma in an Adult Male.
Cureus
November 2024
Department of Medical Oncology, 251 Air Force General Hospital, Athens, GRC.
Olfactory neuroblastoma is an extremely rare malignancy of the sinonasal tract. It is a neuroectodermal tumor, originating from the olfactory epithelium of the nasal and sinus cavities. Due to its rarity, no standard of care treatments have been established to date.
View Article and Find Full Text PDFRecent developments in olfactory neuroblastoma research.
Curr Opin Otolaryngol Head Neck Surg
February 2025
Department of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine.
Article Synopsis
- Olfactory neuroblastoma (ONB) is a rare cancer type from olfactory nerve cells, and a recent review focuses on its diagnosis and treatment challenges.
- New research highlights advancements in genomic profiling and the use of targeted therapies, such as somatostatin analogs and PD-L1 inhibitors, along with insights from genetically engineered mouse models.
- These advancements aim to improve diagnosis and personalize treatment for ONB, potentially enhancing patient outcomes through better imaging, targeted therapies, and collaborative research efforts.
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