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Cerebral Venous Sinus Thrombosis as a Unique Initial Presentation of Thyroid Storm.
Neurologist
January 2025
Public Health, Khamis Mushayt General Hospital, Khamis Mushait, Saudi Arabia.
Introduction: Thyrotoxicosis is associated with a hypercoagulable state, increasing the risk of thrombotic events like CVST. Literature review reveals thyroid hormone's role in promoting prothrombotic abnormalities, impacting coagulation factors and platelet function.
Case Report: This study explores the rare occurrence of thyroid storm complicated by deep cerebral venous sinus thrombosis (CVST) in a young male with no prior history of thyroid disease.
Acute Muscle Weakness in Graves' Disease: A Case Report of Hypokalemic Thyrotoxic Periodic Paralysis.
Cureus
November 2024
Emergency Medicine, Mayo Clinic Arizona, Phoenix, USA.
Thyrotoxic periodic paralysis (TPP) is a rare but significant complication of hyperthyroidism, characterized by episodes of muscle weakness or paralysis and associated hypokalemia. This case report details a 30-year-old Latin American male with a history of Graves' disease, presenting with acute muscle weakness and hypokalemia. The patient reported transient episodes of weakness over recent weeks, culminating in a severe episode prompting emergency evaluation.
View Article and Find Full Text PDFClinical Application of Thyrotropin Receptor Antibodies.
Horm Metab Res
December 2024
Department of Endocrinology and Metabolism, Lanzhou University Second Clinical Medical School, Lanzhou, China.
Thyrotropin receptor antibodies (TRAb) are specific for Graves' disease (GD) and play a crucial role in the pathogenesis of GD. TRAb assays have recently been greatly improved. This review discusses the clinical application of TRAb in the differential diagnosis of hyperthyroidism, the prognosis of GD, GD in gestation and pediatrics, and GD related ophthalmopathy (GO).
View Article and Find Full Text PDFThe role of mitochondrial DNA copy number in autoimmune disease: a bidirectional two sample mendelian randomization study.
Front Immunol
October 2024
Rheumatology and Immunology Department, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Article Synopsis
- Mitochondrial DNA (mtDNA) is linked to autoimmune diseases (AD), and this study used Mendelian randomization to investigate its causal relationship with 13 specific ADs, including rheumatoid arthritis and lupus.
- A two-sample analysis was conducted, comparing mtDNA data from the UK Biobank with AD data from the FinnGen Biobank, using various statistical methods to ensure accuracy.
- Results showed significant associations between mtDNA copy number and several ADs, suggesting mtDNA could be important for future therapeutic strategies in treating these diseases.
Amiodarone Therapy: Updated Practical Insights.
J Clin Med
October 2024
Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Article Synopsis
- Amiodarone is a highly effective antiarrhythmic drug used to treat conditions like atrial fibrillation and ventricular arrhythmias, functioning across all four classes of antiarrhythmics.
- It has a long half-life and complex pharmacokinetics, which can lead to prolonged effects even after stopping the medication, making regular monitoring for side effects like thyroid issues and lung damage essential.
- This paper aims to offer a detailed review of amiodarone's uses, dosing guidelines, interactions with other medications, and necessary monitoring practices.
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