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Pragmatic Language Skills of Turkish Speaking Children Who Stutter.
Folia Phoniatr Logop
January 2025
Introduction: The study aims to investigate the relationship between pragmatic language skills of children who stutter (CWS) and the frequency of stuttering, with a focus on the development of these skills through peer interaction in the school years. It is well-known that CWS may face social disadvantages at school due to their limited peer interaction, which may pose a risk to the development of their pragmatic language skills.
Method: The study involved 64 CWS aged between 60 and 106 months.
Impaired liver function: effect on paclitaxel toxicity, dose modifications and overall survival.
BMC Cancer
December 2024
Department of Clinical Pharmacy, University Medical Center Utrecht, PO Box 85500, Utrecht, 3508 GA, The Netherlands.
Article Synopsis
- The study examines how impaired liver function affects the toxicity of the anticancer drug paclitaxel, specifically focusing on hematological complications, dose modifications, and overall survival rates in cancer patients.
- It analyzes data from 569 patients treated at the University Medical Centre Utrecht between 2011 and 2022, comparing those with normal and impaired liver function based on specific medical criteria.
- Results show that patients with liver impairment experienced significantly higher risks of severe neutropenia and leukopenia, required more dose modifications, and had poorer overall survival in cases of inoperable esophageal and advanced ovarian cancers.
Optical coherence tomography in secondary progressive multiple sclerosis: cross-sectional and longitudinal exploratory analysis from the MS-SMART randomised controlled trial.
J Neurol Neurosurg Psychiatry
December 2024
Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Background: Optical coherence tomography (OCT) inner retinal metrics reflect neurodegeneration in multiple sclerosis (MS). We explored OCT measures as biomarkers of disease severity in secondary progressive MS (SPMS).
Methods: We investigated people with SPMS from the Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial OCT substudy, analysing brain MRIs, clinical assessments and OCT at baseline and 96 weeks.
Speech characteristics that differentiate stuttering and cluttering in Japanese speakers.
Front Psychol
November 2024
Department of Otorhinolaryngology, Head, and Neck Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Background: Cluttering is a speech disorder distinct from stuttering. Despite this distinction, there is no established method to clearly differentiate the two disorders. This study aimed to use objective criteria to differentiate cluttering from stuttering in Japanese speakers.
View Article and Find Full Text PDFInvestigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross-sectional analysis from the MS-STAT2 randomised controlled trial.
Neuroimage Rep
September 2024
NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom.
Background: Deep grey matter pathology is a key driver of disability worsening in people with multiple sclerosis. Quantitative susceptibility mapping (QSM) is an advanced magnetic resonance imaging (MRI) technique which quantifies local magnetic susceptibility from variations in phase produced by changes in the local magnetic field. In the deep grey matter, susceptibility has previously been validated against tissue iron concentration.
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