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Acute hepatitis as a manifestation of secondary syphilis: a case report and literature review.
Pan Afr Med J
September 2024
Department of Hepato-Gastroenterology C, Ibn Sina Hospital, Mohamed V University, Rabat, Morocco.
Article Synopsis
- - A 25-year-old patient with a history of unprotected sex developed cholestatic jaundice and severe itching for two months, leading to an examination that revealed intense jaundice and swollen lymph nodes.
- - Imaging showed edema and lymphadenopathy, while blood tests indicated significant liver enzyme elevation and negative viral serologies, prompting further testing for syphilis, which returned positive.
- - A liver biopsy confirmed syphilitic hepatitis, resulting in treatment with ceftriaxone, which led to remarkable improvement within 48 hours.
Standardised protocol for a prospective international multicentre clinical-based evaluation of point-of-care tests for the screening of genital and extragenital chlamydial and gonococcal infections in men who have sex with men and for the screening of genital chlamydial, gonococcal and infections in at risk women.
BMJ Open
June 2024
Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Article Synopsis
- In 2016, the WHO reported approximately 374 million new infections from four curable STIs: chlamydia, gonorrhoea, syphilis, and trichomoniasis, highlighting the need for effective screening methods.
- Recent advancements in point-of-care tests (POCTs) for these STIs show promising results in lab studies, but there is a lack of clinical performance data, particularly among high-risk groups like men who have sex with men (MSM) and women.
- This research aims to evaluate the effectiveness and user acceptability of molecular-based diagnostic tests (Xpert CT/NG and Xpert TV) for detecting these infections in MSM and women across seven countries, comparing results to established reference tests.
Tertiary syphilis and cardiovascular disease: the united triad: case report.
Eur Heart J Case Rep
March 2024
Cardiology Department, CHU Mohammed VI, Route de Rabat Km 17 BP 398, Gzinaya, Tangier, Morocco.
Background: Syphilis, owing to its natural course, can lead to long-term damage to the aortic valve, such as insufficiency and rarely stenosis, ostial coronary stenosis, and syphilitic aortitis. Cardiovascular involvement alongside neurological involvement dominates the prognosis. This should no longer be seen, thanks to awareness and prevention programmes, medical treatment, and antibiotics.
View Article and Find Full Text PDFExternal quality assessment to support the WHO ProSPeRo study for the evaluation of two dual HIV/syphilis point-of-care tests in seven countries.
BMC Infect Dis
February 2024
Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA.
Background: Sexually transmitted infections (STIs) such as syphilis and HIV remain to be a significant public health issue worldwide. Dual rapid point-of-care tests (POCTs) have shown promise for detecting antibodies to HIV and syphilis but have not been fully evaluated in the field. Our study supported the WHO ProSPeRo study on Sexually Transmitted Infection Point-of-Care Testing (STI POCT) by providing external quality assessment (EQA) for HIV and syphilis testing in reference laboratories and their associated clinical sites in seven countries.
View Article and Find Full Text PDFCase of Secondary Syphilis with Mucocutaneous, Articular, and Pulmonary Involvement in a 74-Year-Old Moroccan Man.
Am J Case Rep
October 2022
Department of Rheumatology, Mohammed VI University Hospital, Marrakech, Morocco.
BACKGROUND Syphilis is a sexually transmitted infection (STI) caused by Treponema pallidum. If untreated, primary syphilis can progress to secondary syphilis, which has a characteristic rash and diverse systemic features. This report is of a case of secondary syphilis with mucocutaneous, articular, and pulmonary involvement.
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