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Platelet indicators do not influence the impact of ABO blood groups on lung adenocarcinoma susceptibility.
Sci Rep
January 2025
Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
The aim of this study was to investigate the role of platelet indicators in the susceptibility of ABO blood groups to lung adenocarcinoma. This was a multicenter retrospective cohort analysis. The study included 528 patients diagnosed with primary lung adenocarcinoma and 528 randomly selected control group patients who were admitted to the Chengdu Fifth People's Hospital from January 2021 to September 2023.
View Article and Find Full Text PDFEpidemiology and laboratory testing of Brucella spondylitis.
Sci Rep
November 2024
Department of Spine Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese PLA, Lanzhou, Gansu, China.
Article Synopsis
- The study focused on patients with Brucella spondylitis (BS), averaging around 52 years old, primarily affecting males, and linked to close contact with livestock and unpasteurized food.
- The diagnostic effectiveness of the Rose Bengal Test (RBT) and Standard Agglutination Test (SAT) was notably high at 94.6%, compared to a low blood culture positivity rate of 7.8%.
- Common symptoms included fever, back pain, and fatigue, with imaging showing the lumbar spine, especially L4/5, as frequently affected; after treatment, the recurrence rate was low at 3.0%.
An Automated pre-Dilution Setup for Von Willebrand Factor Activity Assays.
Bio Protoc
September 2024
R&D Global Medical Affairs, Baxalta Innovations GmbH, a Takeda company, Vienna, Austria.
Article Synopsis
- Accurate measurement of von Willebrand factor ristocetin cofactor activity (VWF:RCo) is essential for diagnosing von Willebrand disease and evaluating VWF products in the pharmaceutical industry, despite current high variability in lab results.
- A new automated method for determining VWF:RCo minimizes manual errors with a pre-dilution setup, leading to consistent results comparable to experienced technicians.
- This operator-independent protocol enhances standardization and efficiency in conducting VWF activity assays while maintaining high precision and accuracy.
Reversible Thrombocytopenia of Functional Platelets after Nose-Horned Viper Envenomation Is Induced by a Snaclec.
Thromb Haemost
September 2024
Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia.
Profound and transient thrombocytopenia of functional platelets without bleeding was observed in patients envenomed by (). This condition was rapidly reversed by administration of F(ab) fragments of immunoglobulin G targeting the whole venom, leaving platelets fully functional. To investigate the potential role of snake venom C-type lectin-like proteins (snaclecs) in this process, -snaclecs were isolated from the crude venom using different liquid chromatographies.
View Article and Find Full Text PDFLaparoscopic liver resection for a patient of hepatocellular carcinoma with von Willebrand disease: a case report.
Surg Case Rep
June 2024
Department of Hepato-Biliary-Pancreatic and Breast Surgery, Ehime University, Ehime University Graduate School of Medicine, 454 Kou, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Article Synopsis
- The text discusses a first case of laparoscopic hepatectomy performed on a 76-year-old male patient with von Willebrand Disease (VWD) type 2B, highlighting the complexity of treating individuals with inherited coagulation disorders.
- The patient had a history of chronic hepatitis C and underwent surgery to remove a 4 cm liver tumor, with unique challenges related to his low platelet count and bleeding risk during the procedure.
- Post-surgery, the patient experienced complications including hemorrhagic fluid drainage and a detected bleed in the greater omentum, indicating the need for careful monitoring following such operations in similar high-risk patients.
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