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Methodological Insights on Biomarker-Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency.
Clin Pharmacol Ther
January 2025
Data Analytics and Methods Task Force, European Medicines Agency, Amsterdam, The Netherlands.
Biomarkers play a pivotal role in the selection and enrollment of trial participants. Particularly, predictive biomarkers help tailor medical care to individual patients; however, also prognostic biomarkers require consideration at the design stage. At the time of initiating a clinical trial, there may be uncertainty about whether a biomarker is predictive or prognostic, and the trial design may need to account for this.
View Article and Find Full Text PDFAssessment of Quality of Life in Mothers of Visually Impaired Children.
J Coll Physicians Surg Pak
January 2025
Al-Shifa School of Public Health, Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
Objective: To assess the factors that affect mothers' quality of life (QOL) and the association of various demographic variables with QOL of the respondents.
Study Design: A cross-sectional survey. Place and Duration of the Study: Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan, from April to September 2023.
Assessment Implementation Measures (AIM): The Journey Towards the Tool Validity.
J Coll Physicians Surg Pak
January 2025
Department of Oral and Maxillofacial Surgery, Frontier Medical and Dental College, Abbottabad, Pakistan.
Objective: To establish the construct validity of the Assessment Implementation Measures (AIM) tool to accurately assess faculty perspectives on implemented assessment systems, facilitating the alignment with set standards.
Study Design: Qualitative Study. Place and Duration of the Study: The study was carried out at RIPHAH International University and data were collected from participants (senior faculty members) involved in teaching and assessment of undergraduates from various medical and dental colleges in Pakistan.
Clinical Outcomes of Definitive Radiotherapy Delivered by Helical Tomotherapy.
J Coll Physicians Surg Pak
January 2025
Department of Radiation Oncology, CyberKnife and Tomotherapy Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
Objective: To assess the disease response and patient survival outcomes for cancer patients treated with helical tomotherapy.
Study Design: Descriptive study. Place and Duration of the Study: The Tomotherapy Unit of Jinnah Postgraduate Medical Centre, Karachi, Pakistan, from October 2020 to August 2023.
Exploring barriers to accessing health care services by young women in rural settings: a qualitative study in Australia, Canada, and Sweden.
BMC Public Health
January 2025
Department of Health Sciences, Carleton University, 2305 Health Sciences Building, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Background: The aim of this study is to explore young rural women's perceived barriers in accessing healthcare services with a focus on the interrelation between three marginalization criteria: age (youth), gender (female), and place of residence (rural areas) in Australia, Canada, and Sweden.
Methods: Using a qualitative interpretive approach, we conducted semi-structured in-depth interviews with 31 young women aged 18 to 24 in selected rural communities. Data collection took place from May 2019 to January 2021, and the qualitative data were analyzed using NVivo software.
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