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Update on Treatment of Hypertension After Renal Transplantation.
Curr Hypertens Rep
May 2021
Department of Internal Medicine 4-Nephrology, University Hospital of Erlangen, Erlangen, Germany.
Purpose Of Review: To incorporate novel findings on pathophysiology and treatment of posttransplant hypertension.
Recent Findings: (1) The sodium retaining effects of CNIs are mediated by stimulation of the thiazide-sensitive sodium chloride co-transporter in the distal convoluted tubule and in this regard chlorthalidone was proven to be an effective antihypertensive drug in renal transplantation. (2) Local and not systemic activation of the renin-angiotensin-aldosterone system plays a crucial role in the pathogenesis of posttransplant hypertension.
Proteinase-activated receptor-2 (PAR2) on blood pressure and electrolyte handling in the late pregnant rat.
Exp Physiol
June 2021
Department of Biology, Appalachian State University, North Carolina Research Campus, Kannapolis, North Carolina, USA.
New Findings: What is the central question of this study? Pregnancy requires marked renal sodium and potassium retention and cumulative plasma volume expansion, in the setting of reduced blood pressure. Research in male rodents has shown that activation of PAR2 can produce peripheral vasodilatation, stimulate renal sodium chloride reabsorption and inhibit renal potassium secretion. Here, we investigate PAR2 activation in virgin and normal pregnant rats.
View Article and Find Full Text PDFTo Curb the Progression of Fatal COVID-19 Course-Dream or Reality.
Curr Hypertens Rep
February 2021
Department of Cardiac & Vascular Surgery, University Hospital of Gdańsk, M. Skłodowskiej-Curie 3a street, 80-210 Gdańsk, Poland.
Purpose Of Review: To analyze the impact of sodium retention states on the course of COVID-19 and propose possible interventions to curb disease progression.
Recent Findings: Numerous data confirm a positive association of non-communicable diseases, aging, and other sodium-retaining states, including iatrogenic ones, with more severe sometimes fatal clinical course of COVID-19. Reasons for this effect could include increased angiotensin signaling via the AT1R receptor.
Contribution of Th17 cells to tissue injury in hypertension.
Curr Opin Nephrol Hypertens
March 2021
Department of Physiology, Medical College of Georgia, Augusta, Georgia, USA.
Purpose Of Review: Hypertension has been demonstrated to be a chief contributor to morbidity and mortality throughout the world. Although the cause of hypertension is multifactorial, emerging evidence, obtained in experimental studies, as well as observational studies in humans, points to the role of inflammation and immunity. Many aspects of immune function have now been implicated in hypertension and end-organ injury; this review will focus upon the recently-described role of Th17 cells in this pathophysiological response.
View Article and Find Full Text PDF-Adrenoceptors: Challenges and Opportunities-Enlightenment from the Kidney.
Cardiovasc Ther
July 2020
University of Pittsburgh School of Medicine, Department of Pharmacology and Chemical Biology, 100 Technology Drive, Room 514, Pittsburgh, PA 15219, USA.
It was indeed a Don Quixote-like pursuit of the mechanism of essential hypertension when we serendipitously discovered -adrenoceptors ( -ARs) in skin-lightening experiments in the frog. Now -ARs lurk on the horizon involving hypertension causality, renal denervation for hypertension, injury from falling in the elderly and prazosin's mechanism of action in anxiety states such as posttraumatic stress disorder (PTSD). Our goal here is to focus on this horizon and bring into clear view the role of -AR-mediated mechanisms in these seemingly unrelated conditions.
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