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The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders.
Curr Med Chem
September 2024
Institute of Biochemistry and Cell Biology, IBBC-CNR, Rome, Italy.
Alcohol use disorders are responsible for 5.9% of all death annually and 5.1% of the global disease burden.
View Article and Find Full Text PDFSerotonin Type 3 Receptor Is Potentially Involved in Cellular Stress Induced by Hydrogen Peroxide.
Life (Basel)
October 2022
OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
Depression is a disease with several molecular mechanisms involved, such as problems in the serotonergic pathway. This disease is very complex and prevalent, and thus important to deeply study and aim to overcome high rates of relapse and therapeutic failure. In this study, two cellular lines were used (HT-22 and SH-SY5Y cells) to gain insight about the role of the serotonin type 3 (5-HT3) receptor in cellular stress induced by hydrogen peroxide and/or corticosterone.
View Article and Find Full Text PDFQuantification of cortisol and its metabolites in human urine by LC-MS: applications in clinical diagnosis and anti-doping control.
Anal Bioanal Chem
September 2022
UNIRELAB Srl, Via Gramsci 70, 20019, Settimo Milanese, MI, Italy.
The objective of the current research was to develop a liquid chromatography-MS (LC-MS) methodology for the determination of free cortisol and its 15 endogenous metabolites (6β-hydroxycortisol, 20α-dihydrocortisol, 20α-dihydrocortisone, 20-β-dihydrocortisol, 20β-dihydrocortisone, prednisolone, cortisone, α-cortolone, β-cortolone, allotetrahydrocortisol, 5α-dihydrocortisol, tetrahydrocortisol, allotetrahydrocortisone, 5β-dihydrocortisol, tetrahydrocortisone) in human urine. Due to its optimal performance, a linear ion trap operating in ESI negative ion mode was chosen for the spectrometric analysis, performing MS and MS experiments. The method was validated for limit of detection (LOD) and limit of quantification (LOQ) (0.
View Article and Find Full Text PDFElectroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine-Immune Therapeutic Mechanisms and Clinical Implications.
Int J Mol Sci
June 2022
Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.
Electroconvulsive therapy (ECT) is based on conducting an electrical current through the brain to stimulate it and trigger generalized convulsion activity with therapeutic ends. Due to the efficient use of ECT during the last years, interest in the molecular bases involved in its mechanism of action has increased. Therefore, different hypotheses have emerged.
View Article and Find Full Text PDFAntidepressant-like effects of a methanol extract of in mice.
Nat Prod Res
December 2022
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Tlalpan, Ciudad de México, México.
This study evaluated the antidepressant-like effects of a methanol extract of in behavioural tests in mice. Our results showed that a single administration of the extract significantly reduced immobility behaviour in the tail suspension test, while three administrations were necessary to diminish immobility behaviour in the forced swimming test. A daily dose of the extract for 28 days improved body weight gain and significantly reduced corticosterone levels of mice exposed to chronic unpredictable mild stress.
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