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Regulation of neural stem cells by innervating neurons.
J Neurochem
January 2025
Neurosciences and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
The adult central nervous system (CNS) hosts several niches, in which the neural stem and precursor cells (NPCs) reside. The subventricular zone (SVZ) lines the lateral brain ventricles and the subgranular zone (SGZ) is located in the dentate gyrus of the hippocampus. SVZ and SGZ NPCs replace neurons and glia in the homeostatic as well as diseased or injured states.
View Article and Find Full Text PDFRed-shifted GRAB acetylcholine sensors for multiplex imaging .
bioRxiv
December 2024
State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China.
The neurotransmitter acetylcholine (ACh) is essential in both the central and peripheral nervous systems. Recent studies highlight the significance of interactions between ACh and various neuromodulators in regulating complex behaviors. The ability to simultaneously image ACh and other neuromodulators can provide valuable information regarding the mechanisms underlying these behaviors.
View Article and Find Full Text PDFA novel anxiety-associated SNP identified in () is associated with decreased protein binding to nicotinic acetylcholine receptors.
Front Behav Neurosci
December 2024
Department of Biological Sciences, Lehigh University, Bethlehem, PA, United States.
Introduction: Anxiety disorders are among the most common mental illnesses in the US. An estimated 31.1% of U.
View Article and Find Full Text PDFThe effect of Naringin on cognitive function, oxidative stress, cholinergic activity, CREB/BDNF signaling and hippocampal cell damage in offspring rats with utero-placental insufficiency-induced intrauterine growth restriction.
Brain Res
January 2025
Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Intrauterine growth restriction (IUGR) induced by utero-placental insufficiency (UPI) results in delayed neural development and impaired brain growth. This study investigates the effects of Naringin (Nar) on memory, learning, cholinergic activity, oxidative stress markers, hippocampal CREB/BDNF signal pathway and cell damage in offspring of rats exposed to UPI. Twenty pregnant Wistar rats were randomly assigned to four groups: control, sham surgery, UPI + NS (UPI + normal saline as a vehicle), and UPI + Nar (UPI + Nar at 100 mg/kg/day).
View Article and Find Full Text PDFEditorial: The non-neuronal cholinergic system in the cardiovascular system: its influence on the heart, vasculature, and the central nervous system.
Front Cardiovasc Med
December 2024
Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
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