The serum and synovial fluid concentrations of alpha2 macroglobulin and alpha2 neuramino glycoprotein of patients with rheumatoid arthritis have been studied. For, both protein fractions have antiprotease activity and inhibit, though to different degrees, many factors concerning inflammation. Even though both fractions have certain activities in common, in rheumatoid arthritis, we neither see a parallel increase nor antagonistic actions in the case of alpha2 macroglobulin and alpha2 neuramino-glycoprotein.
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