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Melatonin, an Antitumor Necrosis Factor Therapy.
J Pineal Res
January 2025
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Tumor necrosis factor (TNF) is a biomarker of inflammation whose levels are elevated in patients with several diseases associated with dysregulation of the immune response. The main limitations of currently used anti-TNF therapies are the induction of immunodepression, which in many cases leads to serious adverse effects such as infection and cancer, and the inability to cross the blood-brain barrier in neuroinflammatory conditions. Melatonin, in addition to being a chronobiotic compound, is widely known for its antioxidant and immunomodulatory capacity to control inflammatory processes in different pathological contexts.
View Article and Find Full Text PDFReal-world multicentre study of cefiderocol treatment of immunocompromised patients with infections caused by multidrug-resistant Gram-negative bacteria: CEFI-ID.
J Infect
January 2025
Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, F-69004 Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, F-69007, France.
Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.
Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023).
High Risk of HPV Related Preneoplastic and Neoplastic Vulvar Lesions in Women Living With HIV.
J Low Genit Tract Dis
December 2024
Neurosurgical Intensive Care Unit, Department of Neuroscience, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Objective: We aimed to investigate the epidemiology of human papilloma virus (HPV)-related preneoplastic and neoplastic vulvar lesions in a large cohort of women living with HIV (WLWH).
Materials And Methods: We retrospectively selected 1,796 WLWH who had a gynecological examination, cervical cytology, high-risk (HR-) HPV test, vulvoscopy, and colposcopy with targeted biopsies when necessary between 1987 and 2020 at 2 Italian institutions. Univariable and multivariable regression analyses were carried out to test the association of the anamnestic and clinical data with the development of precancerous and cancerous lesions.
Hyperinfestation by Strongyloides stercolaris in an immunodepressed patient due to inflammatory bowel disease.
Gastroenterol Hepatol
November 2024
Servicio de Aparato Digestivo, Hospital Universitario Torrecárdenas, Almería, España.
Article Synopsis
- A study was conducted to assess the prevalence of hospital-acquired infections in patients who stayed in the hospital for at least 48 hours, revealing a 12.3% infection rate among the 463 patients studied.
- The majority of infections were urinary, surgical site, and bacteremia, with a notable presence of invasive devices in most cases, and a diverse range of germs identified, including enterobacteria and resistant strains.
- The findings highlight the significant occurrence of nosocomial infections and the importance of further research to better understand and address this issue.
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