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In-silico approach as a tool for selection of excipients for safer amphotericin B nanoformulations.
J Control Release
September 2022
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Deemed University, Elite Status and Centre of Excellence (Maharashtra), N.P. Marg, Matunga (E), Mumbai, 400019, Maharashtra, India. Electronic address:
Safer and efficacious Amphotericin B (AmB) nanoformulations can be designed by augmenting AmB in the monomeric or super-aggregated state, and restricting the aggregated state, by choosing the appropriate excipient, which can be facilitated by employing in-silico prediction as a tool. Excipients selected for the study included linear fatty acids from caprylic (C) to stearic(C) and the stearate based amphiphilic surfactants polyoxyl-15-hydroxystearate (PS15) and polyoxyl-40-stearate (PS40). Blend module was employed to determine the two miscibility parameters mixing energy (E) and interaction parameter (χ).
View Article and Find Full Text PDFSolid-solution fibrous dosage forms for immediate delivery of sparingly-soluble drugs: Part 2. 3D-micro-patterned dosage forms.
Mater Sci Eng C Mater Biol Appl
October 2021
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
In part 1, we have investigated drug release by solid-solution single fibers comprising a sparingly water-soluble drug (ibuprofen) and a highly water-soluble dual excipient (low-molecular-weight hydroxypropyl methyl cellulose (HPMC) and polyoxyl stearate (POS)). In this part, fibrous dosage forms of the same formulation are prepared by 3D-micro-patterning, tested, and modeled. Upon immersion in a small volume of dissolution fluid, the dosage forms rapidly swelled and formed a low-viscosity medium, which subsequently dissolved.
View Article and Find Full Text PDFSolid-solution fibrous dosage forms for immediate delivery of sparingly-soluble drugs: Part 1. Single fibers.
Mater Sci Eng C Mater Biol Appl
April 2020
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Solid solutions of sparingly water-soluble drugs and highly water-soluble excipients are widely used for enhancing the drug delivery rate into the blood stream. The basic physico-chemical mechanisms, however, are not well understood. To delineate the mechanisms, therefore, in this work solid-solution fibers are immersed in a small volume of dissolution fluid and the drug concentration is monitored versus time.
View Article and Find Full Text PDFNanostructured lipid carriers for incorporation of copper(II) complexes to be used against .
Drug Des Devel Ther
May 2017
Department of Drugs and Medicines, Faculdade de Ciências Farmacêuticas, UNESP - Univ Estadual Paulista, Campus Araraquara, Araraquara, SP, Brazil.
Tuberculosis (TB) is a disease caused by . Cessation of treatment before the recommended conclusion may lead to the emergence of multidrug-resistant strains. The aim of this study was to develop nanostructured lipid carriers (NLCs) for use in the treatment of .
View Article and Find Full Text PDFEx-Vivo percutaneous absorption of enrofloxacin: Comparison of LMOG organogel vs. pentravan cream.
Int J Pharm
February 2016
Université Claude Bernard Lyon 1, EA 4169 "Aspects fondamentaux, cliniques et thérapeutique de la fonction barrière cutanée", SFR Lyon-Est Santé, INSERM US 7, CNRS UMS 3453, ISPB, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France; Service Pharmaceutique, Plateforme FRIPHARM, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5 Place d'Arsonval, F-69437 Lyon Cedex 03, France.
The objective of this study was to investigate the percutaneous absorption of enrofloxacin from two base formulations, Pentravan cream and LMOG organogel. Ex-vivo experiments were carried out on pig ear skin. The percutaneous permeation through pig skin of two formulations containing 5 wt% of enrofloxacin was measured and compared using Franz diffusion cells.
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