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Transcription factor specificity protein (SP) family in renal physiology and diseases.
PeerJ
January 2025
Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Dysregulated specificity proteins (SPs), members of the C2H2 zinc-finger family, are crucial transcription factors (TFs) with implications for renal physiology and diseases. This comprehensive review focuses on the role of SP family members, particularly SP1 and SP3, in renal physiology and pathology. A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules.
View Article and Find Full Text PDFThe impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications.
Front Pharmacol
January 2025
Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Carbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of the human body. Dysregulation in the processes of absorption, transport, metabolism, and excretion of these metabolites can lead to the onset of severe metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, gout and hyperbilirubinemia. As the second largest membrane receptor supergroup, several major families in the solute carrier (SLC) supergroup have been found to play key roles in the transport of substances such as carbohydrates, lipids, urate, bile acids, monocarboxylates and zinc ions.
View Article and Find Full Text PDFInteractions Between Toxic Metals and Serum Micronutrient Level in Auto-mechanics in Ibadan Metropolis, Nigeria: a Pilot study.
Biol Trace Elem Res
January 2025
Laboratory for Toxicology and Micronutrient Metabolism, Chemical Pathology Department, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Auto-mechanics who often work without safety measures are vulnerable to the harmful effects of toxic metals like lead (Pb) and cadmium (Cd). These toxic metals exert their deleterious effect by interacting with the micronutrients at their primary site of action. This study aimed to investigate the effects of toxic metal exposure on serum micronutrient levels of auto-mechanics in Nigeria.
View Article and Find Full Text PDFCharacterization, Identification, and Biosafety Evaluation of Multifaceted Traits of Plant Growth-Promoting Endophytes for Ameliorating Productivity of Forage Sorghum.
Curr Microbiol
January 2025
School of Organic Farming, Punjab Agricultural University, Ludhiana, 141004, India.
Endophytes are bacteria that inhabit host plants for most of their life cycle without causing harm. In the study, 15 endophytic bacteria were isolated from 30 forage Sorghum plants and assessed for various plant growth-promoting (PGP) traits, such as phosphate solubilization, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity, ammonia production, siderophore production, gibberellic acid production, Indole-3-acetic acid (IAA) production, and zinc solubilization. One isolate, JJG_Zn, demonstrated multiple PGP activities and was identified as Enterobacter sp.
View Article and Find Full Text PDFSUMOylation of TRIM28 is positively modulated by the BTB/POZ domain of Kaiso.
Mol Biol Rep
January 2025
Federal Research Centre «Fundamentals of Biotechnology», Russian Academy of Sciences, Moscow, Russia, 119071.
Background: TRIM28 plays a crucial role in maintaining genomic stability and establishing imprinting, facilitated by the diversity of KRAB zinc finger proteins. The SUMOylation of TRIM28 is essential for its function and is enhanced in the presence of the KRAB domain. Previously, we demonstrated that Kaiso, another factor capable of interacting with TRIM28, can promote its SUMOylation.
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