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A brief history of the Feulgen reaction.
Histochem Cell Biol
July 2024
Cell Biology and Neurobiology Laboratory, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via A.Ferrata 9, 27100, Pavia, Italy.
One hundred years ago, Robert Feulgen published a landmark paper in which he described the first method to stain DNA in cells and tissues. Although a century has passed since the discovery by Feulgen and Rossenbeck, the chemical reaction still exerts an important influence in current histochemical studies. Its contribution in diverse fields, spanning from biomedicine to plant biology, has paved the way for the most significant studies that constitute our current knowledge.
View Article and Find Full Text PDF[AML treatment strategy based on cytogenetic abnormalities and somatic mutations].
Rinsho Ketsueki
October 2015
Department of Hematology, School of Medicine, Tokyo Women's Medical University.
In addition to morphological and histocytochemical analyses of acute myeloid leukemia (AML), data on cytogenetic abnormalities and somatic mutations are used for classification of AML. The risk stratification based on these examinations facilitates determining the treatment strategy for AML. Cytogenetic risk category definitions by the Southwest Oncology Group (SWOG), Cancer and Leukemia Group B (CALGB), and The Medical Research Council (MRC) classify AML patients into favorable, intermediate, and adverse groups.
View Article and Find Full Text PDFMurine CD200+ CK7+ trophoblasts in a poly (I:C)-induced embryo resorption model.
Reproduction
October 2005
Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Cytokeratin 7 (CK7) is currently regarded as the best marker for trophoblast cells, while CD200 (OX-2), known as 'tolerance signal', plays an important role in normal pregnancy. In this study, the status of CD200 expression was investigated in BALB/c x C57BL/6 and BALB/c x BALB/c mating combinations designed as allogeneic and syngeneic murine models of induced embryo resorption, in which the resorption rate was boosted by an i.p.
View Article and Find Full Text PDFOphthalmoplegia due to mitochondrial DNA disease: the need for genetic diagnosis.
Muscle Nerve
July 2005
School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom.
We describe a patient with chronic progressive external ophthalmoplegia (CPEO) who underwent muscle biopsy for suspected mitochondrial disease. In spite of normal histocytochemical cytochrome c oxidase (COX) activity and respiratory chain enzyme measurements in muscle, subsequent molecular genetic analysis revealed the presence of a single, large-scale deletion of mitochondrial DNA (mtDNA). The case serves to illustrate the importance of pursuing the proposed mitochondrial genetic abnormality, even in patients with normal biopsy findings.
View Article and Find Full Text PDFCombined biochemistry and histocytochemistry as a tool to investigate Ecto-ATPase in the cardiac muscle.
Microsc Res Tech
September 2002
Department of Anatomy and Cell Biology, Kochi Medical School, Kochi 783-8505, Japan.
Ecto-ATPase (ecto-adenosine triphosphatase), a key enzyme of cardiac metabolism, is responsible for modulation of the concentration of extracellular nucleotides in the heart. We present methodology consisting of the combined use of biochemical and histocytochemical techniques to study its properties. Using samples from essentially the same preparation, we applied biochemistry and histocytochemistry to determine biochemical characteristics of ecto-ATPase and an in situ localization of its reactivity.
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