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Fate of pendimethalin in soil and characterization of non-extractable residues (NER).
Sci Total Environ
January 2021
Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.
One important route of degradation of herbicide pendimethalin in soil leads to formation of non-extractable residues (NER). To investigate NER nature (irreversibly, chemically bound, including possible biogenic NER, or strongly sorbed and entrapped) residues of C-labelled pendimethalin in soil were investigated after conventional extraction with organic solvents by silylation. After 400 days of incubation, 32.
View Article and Find Full Text PDFα-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Kγ in THP-1 Monocytes.
J Cell Biochem
July 2017
Vascular Biology Laboratory, JM USDA-Human Nutr. Res. Ctr. on Aging, Tufts University, Boston, Massachusetts 02111.
Article Synopsis
- The CD36 scavenger receptor is involved in binding and internalizing various ligands, including α-tocopherol (αT) and α-tocopheryl phosphate (αTP), which influences cellular signaling and gene expression.
- Research shows that αTP and EPC-K1 trigger stronger internalization of CD36 than αT, and this process is inhibited by sulfo-N-succinimidyl oleate (SSO), affecting the uptake of these compounds differently.
- αTP promotes VEGF expression in monocytes through the CD36/PI3Kγ/Akt signaling pathway, highlighting its role in modulating angiogenesis related to other molecules such as amyloid beta and oxLDL.
Absorption and excretion of colestilan in healthy subjects.
Clin Pharmacokinet
February 2010
Development Project Management Department, Mitsubishi Tanabe Pharma Corporation, Tokyo 103-8405, Japan.
Colestilan, an anion-exchange resin binding both phosphate and bile-acid anions, is under development for the treatment of hyperphosphataemia and dyslipidaemia, which occur in the majority of end-stage renal disease patients. This study using 14C-colestilan was conducted to investigate the absorption and excretion of colestilan in humans. Following a 28-day run-in period with administration of colestilan 3 g three times daily, 12 subjects received a single oral dose of 14C-colestilan 100 mg (approximately 4.
View Article and Find Full Text PDFMetal-activated C-peptide facilitates glucose clearance and the release of a nitric oxide stimulus via the GLUT1 transporter.
Diabetologia
January 2008
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI 48202, USA.
Aims/hypothesis: Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production.
Methods: Erythrocytes obtained from rabbits (n = 11) and both healthy and type 2 diabetic humans (n = 7) were incubated with C-peptide in the absence and presence of Fe2+ and Cr3+, and the resulting ATP release was measured via chemiluminescence.
Control of diferulate formation in dicotyledonous and gramineous cell-suspension cultures.
Planta
January 2008
The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, School of Biological Sciences, The University of Edinburgh, Daniel Rutherford Building, The King's Buildings, Edinburgh, EH9 3JH, UK.
Primary cell wall polysaccharides of some plants carry ester-linked feruloyl groups that can be oxidatively dimerised both within the protoplast and after secretion into the apoplast. Apoplastic dimerisation has been postulated to form inter-polysaccharide cross-links, contributing to wall assembly, but this role remains conjectural. By feeding cultured cells with [14C]cinnamate, we monitored the kinetics of polysaccharide-binding and subsequent dimerisation of 14C-labelled feruloyl groups.
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