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Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis.
Front Immunol
October 2024
Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Article Synopsis
- Particulate matter (PM) exposure can worsen atopic dermatitis (AD), and this study investigates the role of the pregnane X receptor (PXR) in this process.
- The research used mouse models and human skin cells to show that PM increases inflammation and skin issues associated with AD while activating PXR.
- PXR activation helps reduce PM-related inflammation by inhibiting the NF-κB pathway, suggesting that targeting PXR could be a potential treatment strategy for PM-induced AD worsening.
A Case of Parinaud Oculoglandular Syndrome in Which DNA Was Detected in the Cornea and Conjunctiva by Polymerase Chain Reaction.
Medicina (Kaunas)
August 2024
Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Nagasaki, Japan.
Article Synopsis
- Parinaud oculoglandular syndrome (POS) is a condition characterized by unilateral eye inflammation and lymphadenopathy, often linked to infections like cat-scratch disease.
- A 29-year-old man developed POS after adopting a stray cat, experiencing symptoms like fever and eye discharge; tests confirmed the presence of the disease-causing DNA.
- After two weeks of oral medication and two months of topical treatment, the patient's eye condition improved significantly, highlighting the value of PCR testing in diagnosing ocular infections related to POS.
Changes in skin bacterial flora during the healing process of ulcer caused by self-destruction of lymph nodes due to tuberculous lymphadenitis.
J Dermatol
November 2024
Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan.
An 86-year-old woman with residual left hemiplegia from a prior stroke, residing in a nursing facility, presented with swelling of the right side of her neck. Tuberculous lymphadenitis was diagnosed through polymerase chain reaction analysis and sputum culture, leading to treatment with isoniazid, rifampicin, and ethambutol. After 2 months, an abscess and ulcer formed; analysis of the bacterial flora of the ulcer revealed a Pseudomonas infection.
View Article and Find Full Text PDFCombination Therapy of Oral LDN and Topical Pentoxifylline, Rifampin, Clindamycin for Hidradenitis Suppurativa.
Int J Pharm Compd
August 2024
Professional Compounding Centers of America, Houston, Texas, US.
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease that may have profound effects on the patient's quality of life. A personalized HS combination therapy treatment was prescribed to a 54-year-old female suffering from multiple painful sores, as follows: naltrexone capsules titrated from 0.5 mg up to 4.
View Article and Find Full Text PDFA Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics.
ACS Biomater Sci Eng
August 2024
Department of Drug Delivery, Helmholtz Center for Infection Research, Helmholtz-Institute for Pharmaceutical Research Saarland, Campus E8 1, Saarbrücken 66123, Germany.
Hair follicle-penetrating nanoparticles offer a promising avenue for targeted antibiotic delivery, especially in challenging infections like acne inversa or folliculitis decalvans. However, demonstrating their efficacy with existing preclinical models remains difficult. This study presents an innovative approach using a 3D organ culture system with human hair follicles to investigate the hypothesis that antibiotic nanocarriers may reach bacteria within the follicular cleft more effectively than free drugs.
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