Studies of protein binding in homologous series of drugs are of great interest for drug research. Apparent binding constants of phenoxyacetic and phenylacetic acids to horseradish peroxidase and to human serum albumin are evaluated by NMR studies and an optical method. These constants are good parameters to describe hydrophobic interactions, and the results are in a good agreement with our protein binding model described previously.
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Environ Sci Pollut Res Int
November 2022
School of Chemical Engineering, University of Campinas, Albert Einstein Avenue, Campinas, São Paulo, 50013083-852, Brazil.
The sol-gel route was used to synthesize a biophenolic resin from a blend of Kraft black liquor and condensed tannin. The biobased resin has an amorphous structure and diversified surface functional groups. The biomaterial thermal stability was improved by Kraft black liquor, which increased the fixed carbon yield by 19.
View Article and Find Full Text PDFMini Rev Med Chem
June 2021
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Background: The global incidence of type 2 diabetes mellitus (T2DM) has enthused the development of new antidiabetic targets with low toxicity and long-term stability. In this respect, free fatty acid receptor 1 (FFAR1), which is also recognized as a G protein-coupled receptor 40 (GPR40), is a novel target for the treatment of T2DM. FFAR1/GPR40 has a high level of expression in β-cells of the pancreas, and the requirement of glucose for stimulating insulin release results in immense stimulation to utilise this target in the medication of T2DM.
View Article and Find Full Text PDFMolecules
March 2020
Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell'Aquila, Via Vetoio, Coppito, 67100 L'Aquila (AQ), Italy.
Phenoxy acid herbicides are used worldwide and are potential contaminants of drinking water. Reversed phase high-performance liquid chromatography (RP-HPLC) is commonly used to monitor phenoxy acid herbicides in water samples. RP-HPLC retention of phenoxy acids is affected by both mobile phase composition and pH, but the synergic effect of these two factors, which is also dependent on the structure and pKa of solutes, cannot be easily predicted.
View Article and Find Full Text PDFInorg Chem
July 2019
Department of Chemistry and Chemical Engineering , Guangdong Pharmaceutical University, Guangzhou 510000 , People's Republic of China.
Highly efficient and selective removal of pharmaceuticals and personal care products (PPCPs) from wastewater is a great challenge and is significant. In this study, we chose UiO-66-R, which contains eight isostructural metal-organic frameworks (MOFs) with variable functional groups (-R), as a platform for systemically investigating the influence of functionalization on its adsorption behavior with respect to three classic PPCPs. We conducted kinetic, modeling, and structure-function relationship studies on PPCP removal using MOFs.
View Article and Find Full Text PDFChem Res Toxicol
January 2019
Department of Cell Toxicology , Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15 , 04318 Leipzig , Germany.
The effects measured with in vitro cell-based bioassays are typically reported as nominal effect concentrations ( C), but the freely dissolved concentration in the exposure medium ( C) and the total cellular concentration ( C) are considered more quantitative dose metrics that allow extrapolation to the whole-organism level. To predict C and C, the partitioning of the test chemicals to medium proteins and lipids and cells has to be known. In this study, we developed a solid-phase microextraction (SPME) method based on C18-coated fibers to quantify the partitioning of diclofenac, 2,4-dichlorophenoxyacetic acid (2,4-D), ibuprofen, naproxen, torasemide, warfarin, and genistein to bovine serum albumin (BSA), phospholipid liposomes, fetal bovine serum (FBS), and cells.
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