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Population Pharmacokinetics of Orvacabtagene Autoleucel, an Autologous BCMA-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Multiple Myeloma.
Clin Cancer Res
January 2025
Bristol-Myers Squibb (United States), Summit, New Jersey, United States.
Purpose: Orvacabtagene autoleucel (orva-cel; JCARH125), a CAR T-cell therapy targeting B-cell maturation antigen (BCMA), was evaluated in relapsed/refractory multiple myeloma (RRMM) patients in the EVOLVE phase 1/2 study (NCT03430011). We applied a modified piecewise model to characterize orva-cel transgene kinetics and assessed the impact of various covariates on its pharmacokinetics (PK).
Experimental Design: The population PK analysis included 159 patients from the EVOLVE study.
Adenocarpine, Marmesin, and Lycocernuine from Ficus benjamina as Promising Inhibitors of Aldose Reductase in Diabetes: A Bioinformatics-Guided Approach.
Appl Biochem Biotechnol
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Diabetes affects approximately 422 million people worldwide, leading to 1.5 million deaths annually and causing severe complications such as kidney failure, neuropathy, and cardiovascular disease. Aldose reductase (AR), a key enzyme in the polyol pathway, is an important therapeutic target for managing these complications.
View Article and Find Full Text PDFKinetics Difference-driven Organophosphorus Hydrolase-like Nanozyme-Coded Pattern for Identifying -Nitrophenyl Pesticides.
Anal Chem
January 2025
School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, P. R. China.
Organophosphorus pesticides (OPs) are widely used in agricultural production, posing a great threat to human health and the environment. Given that different OPs present different toxicology and toxicities, identifying individual pesticide residues becomes important for assessing food safety and environmental implications. In this work, a kinetics difference-driven analyte hydrolysis strategy is proposed for the first time and validated to identify -nitrophenyl pesticides by developing an organophosphorus hydrolase-like nanozyme-coded sensor array.
View Article and Find Full Text PDFSynthesis of IrCu/CoO hybrid nanostructures and their enhanced catalytic properties toward oxygen evolution reaction under both acidic and alkaline conditions.
Dalton Trans
January 2025
Department of Chemical Engineering, Integrated Engineering Major, College of Engineering, Kyung Hee University, Yongin, 17104, Republic of Korea.
Oxygen evolution reaction (OER) is a half-reaction that occurs at the anode during water electrolysis, and owing to its slow kinetics, it is the rate-limiting step in the process. Alloying with transition metal and combining with transition metal oxide supports are effective methods for modifying the electronic structure of noble metal catalysts and improving their catalytic properties. In this study, we synthesized IrCu/CoO hybrid nanostructures by attaching IrCu alloy nanoparticles onto CoO nanosheets.
View Article and Find Full Text PDFFabrication of Stable Ru-Doped Ni0.95Se Nanostructures for Photovoltaic Coupled Electrochemical Water Splitting in Alkaline Medium.
Chem Asian J
January 2025
Birla Institute of Technology and Science, Vidya Vihar, 333031, Pilani, INDIA.
Development of a competent and stable electrocatalyst coupled with photovoltaic system for the generation of green hydrogen, can be a plausible answer to the existing energy crisis. Herein, we have developed Ru doped Ni0.95Se via hydrothermal method as a bifunctional catalyst for overall water splitting coupled with photovoltaic system.
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