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Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy.
BMJ Oncol
February 2024
Translational Radiobiology, Department of Radiation Oncology, Universitätsklinikum Erlangen & Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
Objective: Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. We aimed to develop a predictive framework based on machine learning (ML) methods to identify FP in advanced NSCLC patients using blood test biomarkers.
Methods And Analysis: We extracted data of 1546 atezolizumab-treated patients from four multicentre clinical trials.
Ionic silver coating of orthopedic implants may impair osteogenic differentiation and mineralization.
Exp Ther Med
March 2025
OrthoLab, The Rudbeck Laboratory, Department of Surgical Sciences/Orthopedics, Uppsala University, 75185 Uppsala, Sweden.
Silver (Ag) possesses potent antimicrobial properties and is used as a coating for medical devices. The impact of silver ions released from orthopedic implants on the differentiation and osteoid formation of different osteogenic cells has yet to be systematically studied. In the present study, human mesenchymal stem cells (hMSCs) and primary human osteoblasts (hOBs) were exposed to different static Ag concentrations (0, 0.
View Article and Find Full Text PDFBone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review.
Mol Clin Oncol
March 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu, Oita 8795593, Japan.
Bone marrow metastasis (BMM) causes pancytopenia and disseminated intravascular coagulation (DIC), resulting in rapid mortality. The incidence of this disease is likely underestimated, with confirmed BMM occurring at approximately twice the rates expected clinically. The present study describes two detailed cases and includes a literature review of BMM caused by ovarian cancer.
View Article and Find Full Text PDF[Translated article] Relationship between lactate dehydrogenase and survival in patients with non-small-cell lung cancer receiving immunotherapy.
Farm Hosp
January 2025
Servicio de Farmacia, Hospital Universitario de la Ribera, Alzira, Spain.
Objective: The expression level of programmed death ligand 1 (PD-L1) is the only approved biomarker for predicting response to immunotherapy, yet its efficacy is not always consistent. Lactate dehydrogenase (LDH) has been associated with tumor aggressiveness and poorer prognosis across various cancer types and may serve as a useful biomarker for monitoring treatment response. The objective of this study is to analyze the relationship between LDH levels prior to the start of treatment with immune checkpoint inhibitors (ICIs) and clinical outcomes in patients with non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFExploring synergistic interactions of ethyl acetate removal and community ecology using magnetite-entrapped biofilters.
Environ Res
January 2025
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering Research Center of Industrial Wastewater Biochemical Treatment, Xiamen 361021, China; Fujian Provincial Research Center of Industrial Wastewater Biochemical Treatment (Huaqiao University), Xiamen 361021, China. Electronic address:
Emissions of ethyl acetate (EA) exhaust from industrial sources can cause environmental and health risks. EA can be effectively removed by biological filtration with low operating costs and promising good benefits. This study demonstrated the synergistic effect of using magnetite and pebbles as bio-packing in promoting microbial activity and microbial abundance for EA degradation.
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