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Recent advances in bacterial outer membrane vesicles: Effects on the immune system, mechanisms and their usage for tumor treatment.
J Pharm Anal
December 2024
Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Tumor treatment remains a significant medical challenge, with many traditional therapies causing notable side effects. Recent research has led to the development of immunotherapy, which offers numerous advantages. Bacteria inherently possess motility, allowing them to preferentially colonize tumors and modulate the tumor immune microenvironment, thus influencing the efficacy of immunotherapy.
View Article and Find Full Text PDFEffect of microbial fertilizers on soil microbial community structure in rotating and continuous cropping .
Front Plant Sci
January 2025
Science and Technology R&D Department, China Chinese Medicine Co., LTD, Beijing, China.
Introduction: is a perennial medicinal plant. It's generally cultivated for three years, and should avoid long-term continuous cultivation. However, unreasonable crop rotation and extensive fertilization are common in cultivation, which leads to the imbalance of soil microflora structure, and the obstacle of continuous cropping are becoming increasingly serious.
View Article and Find Full Text PDFCost-effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in the Chinese healthcare system.
Front Pharmacol
January 2025
Department of Oncology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, China.
Objective: The combination of pembrolizumab and chemotherapy has demonstrated notable clinical advantages in improving overall survival than chemotherapy alone for patients with untreated advanced pleural mesothelioma. The purpose of this study was to assess its cost-effectiveness.
Materials And Methods: A Markov state-transition model was constructed using data from the IND227 phase 3 randomized clinical trial.
Osteoclast visualization: Tartrate-resistant acid phosphatase activity staining using NewFuchsin compatible with non-aqueous mounting and tissue clearing.
MethodsX
June 2025
Laboratory of Cell and Tissue Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Tartrate-resistant acid phosphatase (TRAP) staining is widely used to stain osteoclasts in histological bone sections. The red dye formed by the conventional TRAP enzymatic reaction using naphthol AS-MX (or AS-BI) phosphate and fast red-violet (or garnet) chromogens is readily soluble in alcohol or xylene and requires air-drying prior to cover slipping or the use of an aqueous mounting medium. However, the use of an aqueous mounting medium makes it difficult to store stained specimens for a long time.
View Article and Find Full Text PDFMixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net.
J Bone Oncol
February 2025
School of Mathematics and Computer Science, Quanzhou Normal University, Quanzhou, 362001, China.
Objective: Segmenting and reconstructing 3D models of bone tumors from 2D image data is of great significance for assisting disease diagnosis and treatment. However, due to the low distinguishability of tumors and surrounding tissues in images, existing methods lack accuracy and stability. This study proposes a U-Net model based on double dimensionality reduction and channel attention gating mechanism, namely the DCU-Net model for oncological image segmentation.
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