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Aetiological, seasonal and antibiotic susceptibility patterns of diarrhoeal diseases in Bhutan (2016-2022): a retrospective study of surveillance data.
BMJ Open
January 2025
Enteric Zoonotic and Vector-Borne Disease Laboratory, Royal Centre for Disease Control, Thimphu, Bhutan.
Objectives: This study aimed to identify the aetiological spectrum, seasonal distribution and antimicrobial resistance patterns of diarrhoeal diseases in Bhutan.
Study Design And Setting: The study used a cross-sectional, retrospective analysis of secondary data gathered through a passive, hospital-based sentinel surveillance for diarrhoeal disease across 12 hospitals, representing Bhutan's demographically diverse regions.
Participants: A total of 3429 participants' data of all age groups who presented with diarrhoea at sentinel hospitals between 1 January 1 2016 and 31 December 2022 were analysed.
Effects of commonly used antibiotics on children's developing gut microbiomes and resistomes in peri-urban Lima, Peru.
medRxiv
December 2024
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Background: The effects of antibiotic use on children's gut microbiomes and resistomes are not well characterized in middle-income countries, where pediatric antibiotic consumption is exceptionally common. We characterized the effects of antibiotics commonly used by Peruvian children (i.e.
View Article and Find Full Text PDFEfficacy and tolerability of high-dose cefalexin 45 mg/kg/dose (maximum 1.5 g) three times daily in children with bone and joint infections.
J Antimicrob Chemother
November 2024
Department of General Medicine and Infectious Diseases, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.
Background: Cefalexin, a first-generation cephalosporin, is commonly used as oral continuation therapy for paediatric bone and joint infections (BJIs). The standard four times daily cefalexin dose makes treatment adherence challenging. A pharmacokinetic modelling study found that a cefalexin dose of 45 mg/kg (maximum 1.
View Article and Find Full Text PDFEvaluating pediatric antimicrobial dosing of β-lactam antibiotics for upper respiratory tract infections in emergency and primary care settings.
Am J Health Syst Pharm
November 2024
Department of Pharmacy, Trinity Health Grand Rapids, Grand Rapids, MI, USA.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFDecreasing the Use of Cefdinir for Pediatric Urinary Tract Infections in a Rural Health Care System: A Quasi-experimental Study.
J Pediatric Infect Dis Soc
December 2024
Department of Pediatrics, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, Wisconsin, USA.
There are several antimicrobial options for treating urinary tract infections in children. Although cefdinir is commonly used, better options exist. We developed an intervention bundle to reduce the use of cefdinir in favor of cephalexin.
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