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Genome-scale modeling identifies dynamic metabolic vulnerabilities during the epithelial to mesenchymal transition.
Commun Biol
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Epithelial-to-mesenchymal transition (EMT) is a conserved cellular process critical for embryogenesis, wound healing, and cancer metastasis. During EMT, cells undergo large-scale metabolic reprogramming that supports multiple functional phenotypes including migration, invasion, survival, chemo-resistance and stemness. However, the extent of metabolic network rewiring during EMT is unclear.
View Article and Find Full Text PDFInterplay between tobacco curly shoot virus vsiRNA24 and triosephosphate isomerase: implications for Nicotiana benthamiana viral defense.
New Phytol
December 2024
Chongqing Key Laboratory of Plant Disease Biology, College of Plant Protection, Southwest University, Chongqing, 400715, China.
Virus-derived small interfering RNAs (vsiRNAs) play an important role in viral infection by regulating the expression of host genes. At present, research on the regulation of plant primary metabolic pathways by vsiRNAs is very limited. TvsiRNA24 derived from tobacco curly shoot virus (TbCSV) was amplified by reverse transcription polymerase chain reaction, and its target gene NbTPI (triosephosphate isomerase) was verified using reverse transcription quantitative polymerase chain reaction and GFP fluorescence observation.
View Article and Find Full Text PDFDifferential Mobility Spectrometry Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug Targets.
Anal Chem
December 2024
SCIEX, Concord, Ontario L4K 4V8, Canada.
We report the first implementation of ion mobility mass spectrometry combined with an ultrahigh throughput sample introduction technology for high-throughput screening (HTS). The system integrates differential mobility spectrometry (DMS) with acoustic ejection mass spectrometry (AEMS), termed DAEMS, enabling the simultaneous quantitation of structural isomers that are the substrates and products of isomerase-mediated reactions in intermediary metabolism. We demonstrate this potential by comparing DAEMS to a luminescence assay for the isoform of phosphoglycerate mutase (iPGM) distinctively present in pathogens, offering an opportunity as a drug target for a variety of microbial and parasite borne diseases.
View Article and Find Full Text PDFMolecular characterization and risk analysis of Giardia duodenalis assemblages in corticosteroid-treated and non-treated patients in Ismailia, Arab Republic of Egypt.
Gut Pathog
December 2024
Department of Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, 41522, Egypt.
Background: Giardia duodenalis (G. duodenalis) is an intestinal protozoan parasite of human and animal hosts. The present study investigated and compared the assemblages of G.
View Article and Find Full Text PDFMechanism of jianxin granules in the treatment of heart failure based on proteomics and metabolomics.
Chin Med
November 2024
Ultrasound Department, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian, China.
Article Synopsis
- Heart failure (HF) has high mortality and rehospitalization rates, prompting research into new treatments like Jianxin (JX) granules, a Traditional Chinese Medicine formulation that needs further study for its effectiveness and mechanisms.
- In a study using rats with HF induced by coronary artery ligation, researchers compared JX granules to a model group and standard treatment (Sacubitril/Valsartan) over four weeks, analyzing heart function and various cellular factors.
- Results showed JX granules significantly improved heart performance by enhancing factors like left ventricular ejection fraction and reducing harmful conditions like cardiac fibrosis and oxidative stress, indicating potential as a therapeutic option for HF.
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