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Aqueous extracts of and as promising sources of antibiofilm compounds against mucoid and small colony variants of and .
Biofilm
June 2025
Centre of Biological Engineering, LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal.
Bacterial biofilms formed by and pose significant challenges in treating cystic fibrosis (CF) airway infections due to their resistance to antibiotics. New therapeutic approaches are urgently needed to treat these chronic infections. This study aimed to investigate the antibiofilm potential of various plant extracts, specifically targeting mucoid and small colony variants of and and strains.
View Article and Find Full Text PDFSub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter.
Redox Biol
January 2025
School of Molecular Biosciences, University of Glasgow, G12 8QQ, UK. Electronic address:
Mitochondria are major sites of reactive oxygen species (ROS) production within cells. ROS are important signalling molecules, but excessive production can cause cellular damage and dysfunction. It is therefore crucial to accurately determine when, how and where ROS are produced within mitochondria.
View Article and Find Full Text PDFBioactive Compounds from Vegetal Organs of Species (Dandelion) with Biomedical Applications: A Review.
Int J Mol Sci
January 2025
Institute of Doctoral Studies, Doctoral School of Applied Sciences, Doctoral Field:Biology, "Ovidius" University of Constanta, 58, Ion Voda Street, 900573 Constanta, Romania.
(dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and is well-known for its traditional uses. The aim of this work is to provide a detailed review of scientific literature on the genus from the last two decades, with particular emphasis on the biological and pharmacological characteristics of dandelions. The traditional use of species and their potential use in medicine are assessed.
View Article and Find Full Text PDFAdvances in Fluorescence Techniques for the Detection of Hydroxyl Radicals near DNA and Within Organelles and Membranes.
Antioxidants (Basel)
January 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Hydroxyl radicals (OH), the most potent oxidants among reactive oxygen species (ROS), are a major contributor to oxidative damage of biomacromolecules, including DNA, lipids, and proteins. The overproduction of OH is implicated in the pathogenesis of numerous diseases such as cancer, neurodegenerative disorders, and some cardiovascular pathologies. Given the localized nature of OH-induced damage, detecting OH, specifically near DNA and within organelles, is crucial for understanding their pathological roles.
View Article and Find Full Text PDFProximate Composition and In Vitro Bioactive Properties of Leaf Extracts from Seven Species.
Foods
January 2025
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China.
, an edible wild plant, is valued for its distinctive flavor and health-promoting properties. This study examines the proximate composition, bioactive compounds, and in vitro biological activities of seven leaves (, , , , var. , and ).
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