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Therapeutic interception in individuals at risk of rheumatoid arthritis to prevent clinically impactful disease.
Ann Rheum Dis
January 2025
Academic Department of Rheumatology, Kings College London, London, UK. Electronic address:
Multiple clinical trials for rheumatoid arthritis (RA) prevention have been completed. Here, we set out to report on the lessons learnt from these studies. Researchers who conducted RA prevention trials shared the background, rationale, approach and outcomes and evaluated the lessons learnt to inform the next generation of RA prevention trials.
View Article and Find Full Text PDFCharacterizing brainstem glucagon-like peptide-1 control of sensory-specific-satiety in male and female rats across the estrous cycle.
Biol Psychiatry
January 2025
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
Background: Meal variety promotes overconsumption by delaying sensory-specific-satiety (SSS), the transient reduction in reward value of a recently consumed food. Despite its role in meal cessation, the neuroendocrine mechanisms underlying SSS are largely unknown.
Methods: Here, we developed a preclinical model of SSS wherein rats consume more of a different food compared to the same food presented again, leading to greater caloric intake.
Serum macromineral dynamics and milk production of old Holstein cows submitted to a postpartum delayed milking strategy.
Vet J
January 2025
Department of Eco-friendly Livestock Science, Institute of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, South Korea.
Lactation initiates with a massive Ca secretion into milk. Within 24-48 h post-calving, high-producing, older-parity dairy cows are highly susceptible to Ca disturbances. We hypothesized that the abrupt cessation of milking within this critical period would delay Ca secretion into milk, allowing lactating cows more time to stabilize their Ca homeostasis mechanisms and potentially lower the risk of blood Ca decline in the immediate postpartum period.
View Article and Find Full Text PDFBiosafety and Withdrawal Period of In-Feed Administered Antiparasitic Drug Emamectin Benzoate in Cirrhinus mrigala (Hamilton, 1822).
J Vet Pharmacol Ther
January 2025
Aquatic Animal Health and Environment Division, Central Institute of Brackishwater Aquaculture (CIBA), Chennai, India.
Parasitic infestations are one of the most economically important disease conditions in the Indian major carps including mrigal, Cirrhinus mrigala. This study reported the biosafety and tissue withdrawal of in-feed administered antiparasitic drug, emamectin benzoate (EMB). To evaluate the biosafety of the drug, behaviour, growth and tissue changes in Cirrhinus mrigala was recorded the following in-feed administration of EMB up to 10 times (T1-50 μg kg fish day (1×), T2-125 μg kg fish day (2.
View Article and Find Full Text PDFOsmolarity regulates egg-laying behavior via parallel chemosensory and biophysical mechanisms.
bioRxiv
December 2024
Department of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146.
Animals alter their behavior in response to changes in the environment. Upon encountering hyperosmotic conditions, the nematode worm initiates avoidance and cessation of egg-laying behavior. While the sensory pathway for osmotic avoidance is well-understood, less is known about how egg laying is inhibited.
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