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Comprehensive evaluation of the toxicological effects of commonly encountered synthetic cathinones using in silico methods.
Toxicol Res (Camb)
February 2025
Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Synthetic cathinones (SCs), a group of new psychoactive substances (NPS), are designer molecules with hallucinogenic and psychostimulatory effects. Although the structural similarities of SCs to amphetamines suggest that they may have similar toxicity profiles to those of amphetamine congeners, little is known about SCs from a toxicological point of view. In the present study, the toxicity profiles of commonly encountered SCs ( = 65), listed in the 2020 Report of the United Nations Office on Drugs and Crime (UNODC), were evaluated using in silico methods.
View Article and Find Full Text PDFEpidemiology of acute childhood poisoning in pediatric emergencies in Western Mexico.
Bol Med Hosp Infant Mex
October 2024
Servicio de Pediatría, Hospital Civil de Guadalajara Dr. Juan I. Menchaca.
Article Synopsis
- The study looked at poisoning cases in kids under 16 in Mexico from 2016 to 2020.
- There were 459 cases of poisoning, mostly from venomous animals and medications, and most incidents were accidental.
- Younger kids were mainly poisoned by household products, while older kids were more affected by stimulant drugs.
Post mortem chiral analysis of MDMA and MDA in human blood and hair.
Forensic Sci Int
November 2024
Institute of Legal Medicine, University Medical Centre Hamburg-Eppendorf, Butenfeld 34, Hamburg 22529, Germany.
Drug-related fatalities in the EU are predominantly associated with opioids. MDMA (Ecstasy) consumption results in fewer lethal intoxications despite its widespread use. This study investigates MDMA-related fatalities, focusing on enantiomer ratios of MDMA and its metabolite MDA to explore the role of metabolism in fatal outcomes.
View Article and Find Full Text PDFMalignant Catatonia in the Setting of Acute Methamphetamine and Cocaine Intoxication.
J Addict Med
November 2024
From the College of Medicine, University of Nebraska Medical Center, Omaha, NE (NJM); and Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE (VMMK, AAB).
Background: Malignant catatonia is a potentially lethal neuropsychiatric syndrome characterized by psychomotor abnormalities and autonomic instability. Patients with this syndrome require immediate treatment. Various psychiatric conditions and nonpsychiatric medical problems can trigger malignant catatonia.
View Article and Find Full Text PDFThe cerebellum role in cognition and its functional bi-directional connectivity with prefrontal cortex (PFC) is well recognized. However, how chronic cerebellar dysfunction affects PFC function and cognition remains less understood. Spinocerebellar ataxia type 1 (SCA1), is an inherited, fatal neurodegenerative disease caused by an abnormal expansion of glutamine (Q) encoding CAG repeats in the gene Ataxin-1 (ATXN1) and characterized by severe loss of Purkinje cells (PCs) in the cerebellum.
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