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Auranofin-loaded PLGA Nanoparticles for Neuroprotection against Aluminium-induced Alzheimer's Disease.
Curr Pharm Des
January 2025
Maharaja Ranjit Singh Punjab Technical University Pharma Innovation Lab, Department of Pharmaceutical Sciences & Technology Bathinda India.
Aim: The aim of the current study was to explore nano-formulation for effective neuroprotection by auranofin.
Background: Currently, the treatment options for various CNS disorders, particularly neurodegenerative disorders, are greatly constrained. A significant obstacle in this pursuit is the blood-brain barrier, a shielding covering that hinders the route of numerous biochemical treatments into the brain.
Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer's disease progression.
Front Cell Neurosci
January 2025
Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
For over a century after their discovery astrocytes were regarded merely as cells located among other brain cells to hold and give support to neurons. Astrocytes activation, "astrocytosis" or A1 functional state, was considered a detrimental mechanism against neuronal survival. Recently, the scientific view on astrocytes has changed.
View Article and Find Full Text PDFAltered lumbo-pelvic-hip complex muscle morphometry and contraction change in postpartum pelvic girdle pain and asymptomatic subjects: a cross-sectional study.
Front Physiol
January 2025
College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Objective: Lumbo-pelvic-hip complex muscle training is considered a crucial component of exercise rehabilitation for postpartum women with pelvic girdle pain (PGP). However, there is a paucity of research evidence regarding the morphological changes and contraction function of these muscles in postpartum women with PGP. Understanding the alterations in lumbo-pelvic-hip complex muscles function associated with PGP, is crucial for tailoring effective rehabilitation strategies and promoting optimal postpartum recovery.
View Article and Find Full Text PDFSubstrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype.
Front Immunol
January 2025
Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, United States.
Introduction: Inflammation is a vital immune response, tightly orchestrated through both biochemical and biophysical cues. Dysregulated inflammation contributes to chronic diseases, highlighting the need for novel therapies that modulate immune responses with minimal side effects. While several biochemical pathways of inflammation are well understood, the influence of physical properties such as substrate curvature on immune cell behavior remains underexplored.
View Article and Find Full Text PDFExposure of Apis mellifera (Hymenoptera: Apidae) colonies to imidacloprid impairs larval development, promotes oxidative stress in pupae, and induces changes in the midgut of adult bees.
Biol Res
January 2025
Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Maringá, Paraná, 87020-900, Brazil.
Bees are essential pollinators that contribute to maintaining biodiversity and increasing agricultural production. However, by foraging on agricultural crops, bees may become contaminated with compounds used for pest control. In this study, we exposed bee (Apis mellifera L.
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