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Multi-Omics Research on Angina Pectoris: A Novel Perspective.
Aging Dis
December 2024
Department of Psycho-cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused by insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia and hypoxia. Long-term AP typically induces other cardiovascular events, including myocardial infarction and heart failure, posing a serious threat to patient safety. However, AP's complex pathological mechanisms and developmental processes introduce significant challenges in the rapid diagnosis and accurate treatment of its different subtypes, including stable angina pectoris (SAP), unstable angina pectoris (UAP), and variant angina pectoris (VAP).
View Article and Find Full Text PDFAssociation of Angina, Myocardial Infarction and Atrial Fibrillation-A Bidirectional Mendelian Randomization Study.
Br J Hosp Med (Lond)
September 2024
Department of Cardiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Article Synopsis
- - The study investigates the causal relationship between coronary heart disease (CHD), coronary atherosclerosis, angina, myocardial infarction (MI), and atrial fibrillation (AF) using a method called two-sample Mendelian randomization.
- - Mendelian randomization relies on genetic variations to assess causality, based on three key assumptions: the genetic variant relates to the exposure, is free of confounding factors, and only influences the outcome through that exposure.
- - Findings suggest a genetic link where CAAs, angina, and MI increase the risk of AF, and AF may also heighten the risk of CAAs, highlighting the importance of regular monitoring and appropriate treatment for patients with CHD and AF. *
[Vasospastic angina : an underdiagnosed pathology].
Rev Med Suisse
September 2024
Service de cardiologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Vasospastic angina (VSA) was first described in 1959 by Myron Prinzmetal as "the variant form of angina pectoris" on the sole basis of medical history and ECG. This condition is currently categorized as an endotype of myocardial infarction without coronary obstruction (Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA)). Diagnostic criteria have been suggested by expert consensus.
View Article and Find Full Text PDFInvestigating Genetic Overlap between Alzheimer's Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis.
Int J Mol Sci
August 2024
Centre for Precision Health, Edith Cowan University, Joondalup, WA 6027, Australia.
There is evidence to support a link between abnormal lipid metabolism and Alzheimer's disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between AD and coronary artery disease (CAD). However, the intricate biological mechanisms of AD are poorly understood, and its relationship with lipids and CAD traits remains unresolved.
View Article and Find Full Text PDFRNF213 Variants, Vasospastic Angina, and Risk of Fatal Myocardial Infarction.
JAMA Cardiol
August 2024
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.
Importance: Vasospastic angina (VSA) is vasospasm of the coronary artery and is particularly prevalent in East Asian populations. However, the specific genetic architecture for VSA at genome-wide levels is not fully understood.
Objective: To identify genetic factors associated with VSA.
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