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Outcome Predictors of Generalized Myasthenia Gravis: A Prospective Observational Study.
Ann Indian Acad Neurol
January 2025
Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Background And Objectives: There is paucity of studies on long-term remission of autoimmune generalized myasthenia gravis (MG) from Southeast Asia. We report the outcome predictors of generalized MG and also evaluate the influence of high- versus low-dose prednisolone and prednisolone with or without azathioprine (AZA).
Methods: Fifty-seven patients with generalized MG were included, who completed 2 years of follow-up.
A Rare Case of Autoimmune Enteropathy After Thymectomy.
Cureus
December 2024
Graduate Medical Education, Eisenhower Health, Rancho Mirage, USA.
Autoimmune enteropathy (AIE) is a rare cause of chronic diarrhea associated with autoantibodies and susceptibility to other autoimmune diseases, such as rheumatoid arthritis, diabetes, autoimmune hemolytic anemia, and atopic dermatitis. While it is more common in children, the prevalence of AIE in adults is increasing. Due to the nonspecific nature of its presenting symptoms and the lack of consistent findings, AIE can be challenging to diagnose.
View Article and Find Full Text PDFMyasthenia Gravis Complicated by M-proteinemia and Demyelinating Neuropathy: A Report of Two Cases.
Cureus
December 2024
Department of Neurology, Seirei Hamamatsu General Hospital, Hamamatsu, JPN.
Myasthenia gravis (MG) is characterized by weakness and rapid fatigue of voluntary muscles. Here, we present two cases of early-onset MG, complicated with M-proteinemia and demyelinating neuropathy. Case one was diagnosed with MG at age 29, received tacrolimus post-thymectomy, and developed M-proteinemia and demyelinating neuropathies at age 66 before being diagnosed with B-cell lymphoma.
View Article and Find Full Text PDFImpact of SARS-CoV-2 infection on patients with myasthenia gravis: a retrospective study in a Chinese population.
Front Neurol
December 2024
Center of Treatment of Myasthenia Gravis, People's Hospital of Shijiazhuang, Shijiazhuang, China.
Background And Purpose: Myasthenia gravis (MG) is characterized by fluctuating muscle weakness due to immune-mediated damage to acetylcholine receptors. Viral infections can exacerbate symptoms of muscle weakness, and the clinical status of patients with MG may influence the outcomes of such infections. Here, we identified factors of symptom exacerbation, severe SARS-CoV-2 infection, and pneumonia in patients with MG who are infected with SARS-CoV-2.
View Article and Find Full Text PDFYellow fever vaccination and the thymus in adults with congenital heart disease.
Int J Cardiol Congenit Heart Dis
March 2024
Royal Brompton and Harefield NHS Trust and Imperial College London, UK.
Aim: To highlight the potential lack of documentation of thymectomy on historic cardiac operation notes and how this impacts the safety of the yellow fever vaccination for patients who have had congenital heart surgery in childhood.
Background: With advances in treatment, the population of adults with congenital heart disease (ACHD) is ever growing. Consequently, increasing numbers of patients wish to travel and work abroad.
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