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Factors related to the choice of warfarin for treating newly diagnosed nonvalvular atrial fibrillation are associated with safety outcomes during anticoagulation: A new-user, active-comparator, retrospective cohort study.
J Arrhythm
December 2024
Department of Clinical Research and Management, Graduate School of Medicine University of the Ryukyus Nishihara Okinawa Japan.
Background: Direct oral anticoagulants (DOACs) are preferred for stroke prevention in nonvalvular atrial fibrillation (NVAF); however, warfarin is still used. This study examined why physicians may choose warfarin over DOACs and the associated safety outcomes in patients with NVAF.
Methods: We conducted a new-user, active-comparator cohort study in newly diagnosed patients with NVAF to assess safety outcomes after the introduction of DOACs in Japan.
Bilateral occipital infarcts due to persistent migraine with aura in an elderly.
Agri
January 2024
Department of Radiology, Bodrum American Hospital, Muğla, Türkiye.
Migrainous infarction is a rare complication of migraine that mostly occurs in the posterior circulation and in younger women, with an incidence of less than 1%. It is known that migraine, especially migraine with aura, is a risk factor for ischemic stroke in younger adults but not in the elderly. We report a 71-year-old male patient who experienced abnormal visions due to migraine headache and persistent aura, causing bilateral occipital infarcts.
View Article and Find Full Text PDFReversible cerebral vasoconstriction syndrome post-cardiac transplantation: a therapeutic dilemma: case report.
BMC Neurol
August 2024
Department of Stroke, The Alfred, Melbourne, VIC, Australia.
Background: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by diffuse, multifocal segmental narrowing of cerebral arteries and can result in ischaemic stroke. Causal factors, identified in 60% of cases, include immunosuppressant pharmacotherapy. The few reports following heart transplantation are almost all in Asian recipients.
View Article and Find Full Text PDFDeficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca channel.
Basic Res Cardiol
October 2024
Institute for Molecular Medicine III, University Hospital Düsseldorf and Heinrich Heine University, Düsseldorf, Germany.
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is involved in cardiac function. Hypertension-induced cardiac remodeling was induced by 4-weeks Angiotensin II (AngII) administration and assessed by echocardiography.
View Article and Find Full Text PDFPotential interactions between medications for rate control and direct oral anticoagulants: Population-based cohort and case-crossover study.
Heart Rhythm
December 2024
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Background: Direct oral anticoagulants (DOACs) are commonly co-prescribed with amiodarone/diltiazem/verapamil, but whether there is a drug interaction between these drugs is unclear.
Objective: The purpose of this study was to investigate the risk of clinical outcomes associated with concomitant use of DOACs and amiodarone/diltiazem/verapamil.
Methods: We identified DOAC users in the Clinical Practice Research Datalink Aurum from January 1, 2011, to December 31, 2019.
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