Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Global phylogenomic analysis of reveals genomic and prophage diversity in multidrug-resistant lineages.
Microb Genom
March 2025
Discipline of Microbes, Infection and Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
is the foremost cause of opportunistic canine skin and mucosal infections worldwide. Multidrug-resistant (MDR) and methicillin-resistant (MRSP) lineages have disseminated globally in the last decade and present significant treatment challenges. However, little is known regarding the factors that contribute to the success of MDR lineages.
View Article and Find Full Text PDFDevelopment of a T cell engaging bispecific antibody targeting long non-coding RNA PVT1.
Cancer Immunol Immunother
March 2025
Department of Pathology, School of Medicine, Sapporo Medical University, South-1, West-17, Chuo-Ku, Sapporo, Hokkaido, 060-8556, Japan.
The development of effective immunotherapies for solid tumors remains a significant challenge. In previous studies, we identified PVT1, a long non-coding RNA, with the peptide HF10 derived from PVT1, presented by HLA-A24. This study aims to develop a single-chain variable fragment (scFv) that specifically recognizes the HLA-A24/HF10 complex (HF10 scFv) and to evaluate its specificity, reactivity, and therapeutic potential as part of a T cell engaging bispecific antibody (HF10xCD3) in vitro and in vivo.
View Article and Find Full Text PDFWhole-Genome Shotgun Sequencing from Chicken Clinical Tracheal Samples for Bacterial and Novel Bacteriophage Identification.
Vet Sci
February 2025
Exotic and Emerging Avian Diseases Research Unit, U.S. National Poultry Research Center, Agricultural Research Service, U.S. Department of Agriculture (USDA), 934 College Station Road, Athens, GA 30605, USA.
A whole-genome shotgun sequencing (sWGS) approach was applied to chicken clinical tracheal swab samples during metagenomics investigations to identify possible microorganisms among poultry with respiratory diseases. After applying shotgun sequencing, (ORT) and a putative prophage candidate were found in one of the swab samples. A multi-locus sequence typing (MLST) scheme of the ORT genome involved the adk, aroE, fumC, gdhA, pgi, and pmi genes.
View Article and Find Full Text PDFPopulation genetic analysis of clinical complex strains in China.
Front Cell Infect Microbiol
February 2025
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
Background: To explore the genetic characteristics of the complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria.
Methods: We conducted population genetic analyses on 360 MABC genomes from China, focusing on core genome multilocus sequence typing (cgMLST), pan-genome characterization, population genetics, and antimicrobial resistance gene profiling.
Results: Our analysis identified 273 subsp.
Whole-genome evaluation and prophages characterization associated with genome of carbapenem-resistant Acinetobacter baumannii UOL-KIMZ-24-2.
Curr Genet
January 2025
Industrial Biotechnology Division, National Institute for Biotechnology and Genetic Engineering-College, Pakistan Institute of Engineering and Applied Sciences, Islamabad, 44000, Pakistan.
Carbapenem-resistant Acinetobacter baumannii (CRAB) is an emerging threat to healthcare settings in many countries, principally in South Asia. The current study was aimed to identify, evaluate whole-genome and characterize the prophages in genome of CRAB strain, recovered from patients of Lahore General Hospital, Lahore. More than 200 samples were collected and identified by morphological and biochemical tests.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!