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Advancing de novo lipogenesis: Genetic and metabolic insights.
Cell Metab
January 2025
Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA. Electronic address:
De novo lipogenesis (DNL) is the process whereby cells synthesize fatty acids from acetyl-CoA, contributing to steatosis in fatty liver disease. Two new studies, using genetic mouse models, metabolomics, and pharmacology, identified alternative pathways in DNL and unexpected physiological effects when targeting key enzymes in this pathway.
View Article and Find Full Text PDFiTRAQ-based quantitative proteomic analysis of herbicide stress in Avena ludoviciana Durieu.
Sci Rep
January 2025
Iranian Research Institute of Plant Protection, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran.
Winter wild oat (Avena sterilis subsp. ludoviciana (Durieu) Gillet & Magne) has been considered the most common and troublesome weed in wheat fields of Iran. The widespread and continuous use of herbicides has led to the emergence and development of resistant biotypes in A.
View Article and Find Full Text PDFPantothenate kinase 4 controls skeletal muscle substrate metabolism.
Nat Commun
January 2025
Department of Molecular Physiology of Exercise and Nutrition, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.
Article Synopsis
- Metabolic flexibility in skeletal muscle is crucial for healthy glucose and lipid metabolism, and its dysfunction can lead to metabolic diseases.
- Exercise improves metabolic flexibility and helps identify mechanisms that support metabolic health.
- The study reveals that pantothenate kinase 4 (PanK4) is vital for muscle metabolism, as its deletion disrupts fatty acid oxidation and elevates harmful acetyl-CoA levels, which lead to glucose intolerance, while increasing PanK4 enhances glucose uptake and lowers acetyl-CoA.
Oxymatrine reduces hepatic lipid synthesis in rat model of nonalcoholic steatohepatitis by regulating Sirt1/AMPK and LXR/Plin2/SREBP-1c pathways.
Chem Biol Interact
December 2024
Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou, 310003, China. Electronic address:
Nonalcoholic Steatohepatitis (NASH) is a common liver disease with limited treatment options. Oxymatrine (OMT) has been reported to treat liver diseases effectively. This study aims to explore the mechanisms of OMT in NASH.
View Article and Find Full Text PDFP46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers.
Am J Pathol
December 2024
Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, California; Palo Alto VA, Palo Alto, California. Electronic address:
Mitochondrial maladaptation and dysfunction contribute to the progression of metabolic dysfunction-associated steatohepatitis (MASH). The authors recently implicated the induction of Shc in progressive MASH during aging and the cytoplasmic p52Shc isoform in the activation of redox enzyme NOX2. The mitochondrial Shc isoform p46Shc was shown to repress acetyl-coenzyme A acyltransferase 2 (ACAA2) in vitro.
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