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Effect-based analysis of endocrine effects in surface and ground water with focus on progestagenicity using Arxula yeast-based reporter gene assays.
Environ Toxicol Chem
January 2025
Institut für Umwelt & Energie, Technik & Analytik e. V. (IUTA), Duisburg, Germany.
The use of effect-based methods in water monitoring for identifying risks to aquatic organisms and human health is important for aiding regulatory decisions. In the past decades, the database on monitoring, especially in surface waters, has grown as this aquatic environment is openly exposed to various contamination sources. With regard to endocrine disruption, estrogenic and androgenic effects have been primarily investigated.
View Article and Find Full Text PDFAcupuncture and Bushen Quyu decoction improved endometrial receptivity, hormone secretion, and uterine artery blood flow for repeated implantation failure patients undergoing in vitro fertilization and embryo transfer.
Drug Discov Ther
January 2025
Department of Obstetrics and Reproductive Immunology, Shanghai East Hospital of Tongji University, Shanghai, China.
Acupuncture and traditional Chinese medicine (TCM) have shown certain benefits in assisted in vitro fertilization and embryo transfer (IVF-ET). In this study, we evaluated the efficacy and safety of the combination of acupuncture combined with the Bushen Quyu decoction in patients with failures of IVF-ET. This study was conducted at Shanghai Yangpu District Hospital of TCM from May to November of 2021.
View Article and Find Full Text PDFAnalysing physiological urinary hormonal changes in female red pandas during the breeding season.
Acta Vet Hung
December 2024
2College of Veterinary Medicine, Kyungpook National University, Buk-gu, Daegu, 41566, Korea.
This study aimed to contribute to the conservation of red pandas by improving the understanding of their oestrus cycle through examining urinary hormone changes during their breeding season. To minimize stress associated with blood sample collection, we used urine samples Sex hormone levels were measured over six months in pregnant and nonpregnant red pandas, to help understand changes in oestrogen concentrations during oestrus, post-mating progesterone concentrations and differences in ceruloplasmin concentrations. The results of the study revealed that female red pandas are polyoestrous, with a second oestrogen peak after mating.
View Article and Find Full Text PDFEffects of parabens on human and rat placental 3β-hydroxysteroid dehydrogenase isoforms: Structure activity relationship and docking analysis.
J Steroid Biochem Mol Biol
January 2025
Department of Pharmacy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China. Electronic address:
Parabens are widely used as preservatives in personal care products and are linked to potential disruptions in placental steroidogenesis. However, their exact impact remains unclear. This study aimed to explore the inhibition, mechanisms, structure-activity relationships (SAR) of parabens on human placental 3β-hydroxysteroid dehydrogenase type 1 (h3β-HSD1) and its rat counterpart, r3β-HSD4.
View Article and Find Full Text PDFOvarian Stimulation Effects on Ghrelin Secretion and Reproductive Potential.
Clin Endocrinol (Oxf)
February 2025
Instituto de Fisiología, Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba and Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET) - Universidad Nacional de Córdoba, Córdoba, Argentina.
Objective: Finely regulated Ghrelin (Ghrl) secretion is essential during early pregnancy, as infra or supraphysiologic levels can be detrimental. Since oestrogens stimulate Ghrl synthesis, ovarian stimulation (OS) might increase ghrelinemia, thus being detrimental for fertility. The aim of this work was to evaluate whether OS increases ghrelinemia and associates with maternal endocrine and immune biomarkers and reproductive success.
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