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Toxicity of rare earth elements europium and samarium on zebrafish development and locomotor performance.
J Hazard Mater
January 2025
Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha 410012, China. Electronic address:
Rare earth elements are integral to modern technology, but their increasing environmental distribution due to anthropogenic activities poses potential health risks to humans. This study utilized zebrafish as a model to assess developmental and locomotor performance effects of europium and samarium. Exposure to Eu or Sm induced a reduction in heart rate, growth inhibition, and morphological deformities.
View Article and Find Full Text PDFBio-fabrication of chitosan-stabilized magnesium oxide nanomaterials: Investigation of photocatalytic, in vitro cytotoxicity activities and apoptosis in oral squamous carcinoma cells.
Int J Biol Macromol
January 2025
Centre of Advanced Study in Marine Biology, Annamalai University, Parangipettai 608 502, Tamil Nadu, India.
A bio-fabrication approach is a novel way to develop chitosan-stabilized magnesium oxide nanomaterials (cMgO-NMs). The process involves utilizing polymeric chitosan as the reducing and stabilizing agent. The characteristics of the developed cMgO-NMs were determined using various spectroscopical techniques.
View Article and Find Full Text PDFEvaluating binding behavior of quercetin to human serum albumin and calf thymus DNA: Insights from molecular dynamics, spectroscopy, and apoptotic pathway regulation.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran. Electronic address:
In this work, we sought to apprehend quercetin binding affinity and its interaction behavior in complex with human serum albumin (HSA) and calf thymus DNA (ctDNA) through multi spectroscopy and molecular dynamics and also evaluated its effects on colorectal cancer. The binding constants of ctDNA-quercetin and HSA-quercetin complexes at 298 K, which were calculated to be (2.67 ± 0.
View Article and Find Full Text PDFNeuroprotective Assessment of Nutraceutical (Betanin) in Neuroblastoma Cell Line SHSY-5Y: An in-Vitro and in-Silico Approach.
Neurochem Res
December 2024
Division of Biotechnology, School of Life Sciences, JSS Academy of Higher Education and Research, Ooty Campus, Ooty, India.
The cognitive dysfunction in the brain cause severe pathological consequences such as Alzheimer's disease (AD), Parkinson's disease. The current treatments are cost expensive and also cause negative side effects. Therefore it is inevitable to develop natural phyto-compounds as a drug like molecules to treat neurodegenerative diseases.
View Article and Find Full Text PDFExposure to an environmentally representative mixture of polybrominated diphenyl ethers (PBDEs) alters zebrafish neuromuscular development.
Neurotoxicology
December 2024
INRS - Centre Armand Frappier Santé Biotechnologie, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada. Electronic address:
Polybrominated diphenyl ethers (PBDEs) are a prevalent group of brominated flame retardants (BFRs) added to several products such as electronics, plastics, and textiles to reduce their flammability. They are reported as endocrine disruptors and neurodevelopmental toxicants that can accumulate in human and wildlife tissues, thus making their ability to leach out of products into the environment a great cause for concern. In this study, zebrafish (Danio rerio) embryos and larvae were exposed to a wide concentration range (1.
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